ArticleDiabetes care2015
Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes.
Article in Diabetes care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiorespiratory Fitness and Physical Activity in Pediatric Diabetes: A Systemic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- The Oxygen Transport Cascade During Maximal-Intensity Exercise in Uncomplicated Type 1 Diabetes: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2026Review
- A ketogenic diet enhances aerobic exercise adaptation and promotes muscle mitochondrial remodeling in hyperglycemic male mice.Nature communications · 2026Article
- Effects of 12-week combined interval running and resistance training on cardiac structure and performance in patients with type 1 diabetes.Therapeutic advances in endocrinology and metabolism · 2025Article
- Association Between Microvascular Disease and Cardiorespiratory Fitness Among Adults With Type 2 Diabetes.Diabetes care · 2024Article
- Article
- Association of HbA1c with VOMetabolites · 2022Review
- Sex-Related Differences in Cardiovascular Disease Risk Profile in Children and Adolescents with Type 1 Diabetes.International journal of molecular sciences · 2021Review
- Cardiovascular risk and heart rate variability in young adults with type 2 diabetes and arterial stiffness: The SEARCH for Diabetes in Youth Study.Journal of diabetes and its complications · 2020Article
- The changing face of paediatric diabetes.Diabetologia · 2020Review
- Macrovascular disease and risk factors in youth with type 1 diabetes: time to be more attentive to treatment?The lancet. Diabetes & endocrinology · 2018Review
- Social Determinants of Health Are Associated with Markers of Renal Injury in Adolescents with Type 1 Diabetes.The Journal of pediatrics · 2018Article
- Article
- Predictors of improvements in exercise capacity during cardiac rehabilitation in the recovery phase after coronary artery bypass graft surgery versus acute myocardial infarction.Heart and vessels · 2018Article
- Urinary markers in the early stage of nephropathy in patients with childhood-onset type 1 diabetes.Pediatric nephrology (Berlin, Germany) · 2016Article
- Insulin sensitivity and complications in type 1 diabetes: New insights.World journal of diabetes · 2015Review
- A Quality Initiative Reducing Adverse Outcomes in Pediatric Patients with DKA During Intrafacility Transit.Pediatric quality & safetyArticle
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Authors and funding
9 authors.
Funding
Abstract
objectiveDiabetic nephropathy and cardiovascular disease are strongly related in adults with type 1 diabetes, yet little is known about this relationship in adolescents prior to the onset of detectable clinical disease. We hypothesized that cardiopulmonary fitness would be directly associated with albumin-to-creatinine ratio (ACR) and inversely related to estimated glomerular filtration rate (eGFR) in adolescents with type 1 diabetes. RESEARCH DESIGN AND
methodsSixty-nine adolescents with type 1 diabetes and 13 nondiabetic control subjects of similar pubertal stage and BMI had insulin sensitivity (glucose infusion rate [GIR]), measured by hyperinsulinemic-euglycemic clamp, and lean body mass, measured by DEXA. Cardiopulmonary fitness was measured by cycle ergometry to obtain peak volume of oxygen (VO2peak), and renal function was measured by eGFR using the Bouvet equation (measuring creatinine and cystatin C levels) and ACR.
resultsAdolescents (15.5 ± 2.2 years of age) with type 1 diabetes (6.3 ± 3.8 years diabetes duration) had reduced VO2peak (31.5 ± 6.3 vs. 36.2 ± 7.9 mL/kg ⋅ min, P = 0.046) and VO2peak/lean kg (43.7 ± 7.0 vs. 51.0 ± 8.6 mL/lean kg ⋅ min, P = 0.007) compared with nondiabetic control subjects. eGFR was inversely associated with VO2peak and VO2peak/lean kg after adjusting for sex, Tanner stage, GIR, HbA1c level, systolic blood pressure, and LDL cholesterol level (β ± SE, VO2peak: -0.19 ± 0.07, P = 0.02; VO2peak/lean kg: -0.19 ± 0.09, P = 0.048). Moreover, participants in the highest tertile for eGFR had significantly lower sex- and Tanner-adjusted VO2peak and VO2peak/lean kg compared with participants in the lowest tertile.
conclusionsAdolescents with type 1 diabetes had reduced exercise capacity, which was strongly associated with renal health, independent of insulin sensitivity. Future studies should examine the underlying interrelated pathophysiology in order to identify probable targets for treatment to reduce cardiovascular and renal complications.
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