Evidence map›Paper›PMID 25414152›Full record

Trial reportDiabetes care2015

Mild gestational diabetes mellitus and long-term child health.

Mark B Landon, Madeline Murguia Rice, Michael W Varner, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Joseph R Biggio, John M Thorp, Edward K Chien and 5 more

2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 127 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00069576 nacompletednot on this map

A Randomized Clinical Trial of Treatment for Mild Gestational Diabetes Mellitus

TypeinterventionalSponsorThe George Washington University Biostatistics CenterRan2002 to 2013Enrolled7,381ConditionsDiabetes, GestationalArmsnutritional counseling, self blood glucose monitoring
NCT03523143 naterminatednot on this mapstarted 2018, after this paper: background citation

The Effect of Early Screening and Intervention for Gestational Diabetes Mellitus on Pregnancy Outcomes: the TESGO Randomized Trial

TypeinterventionalSponsorNational Taiwan University HospitalRan2018 to 2022Enrolled967ConditionsPregnancy Complications, Gestational Diabetes Mellitus in PregnancyArmsearly screening and intervention, standard screening and intervention
3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Insulin for the treatment of women with gestational diabetes.The Cochrane database of systematic reviews · 2017
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Diabetes in pregnancy and infant adiposity: systematic review and meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2017
    Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  14. Observational
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Mark B LandonDepartment of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH mark.landon@osumc.edu.
Madeline Murguia RiceGeorge Washington University Biostatistics Center, Washington, DC.
Michael W VarnerDepartment of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT.
Brian M CaseyDepartment of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX.
Uma M ReddyEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Ronald J WapnerDepartment of Obstetrics and Gynecology, Columbia University, New York, NY.
Dwight J RouseDepartment of Obstetrics and Gynecology, Brown University, Providence, RI.
Joseph R BiggioDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL.
John M ThorpDepartment of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Edward K ChienDepartment of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, OH.
George SaadeDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX.
Alan M PeacemanDepartment of Obstetrics and Gynecology, Northwestern University, Chicago, IL.
Sean C BlackwellDepartment of Obstetrics and Gynecology, University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, TX.
J Peter VanDorstenDepartment of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network

Funding

Data Coord Ctr-NICHD Cooperative Multicenter Maternal Medicine Units Research NetU10HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI CLIFTON, REBECCA GERSNOVIEZ · 2009 to 2021
$174.2M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
MATERNAL FETAL RESEARCH NETWORK: DATA COORDINATING CTRU01HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI THOM, ELIZABETH ANN · 1998 to 2008
$27.0M
YOGA, IMMUNE FUNCTION, AND HEALTHM01RR000034 · NCRR · OHIO STATE UNIVERSITY · PI PASKETT, ELECTRA D. · 1985 to 2008
$22.7M
The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
NICHD Maternal Fetal Medicine Units NetworkU10HD034116 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI CASEY, BRIAN M · 1996 to 2015
$19.3M
NICHD Maternal Fetal Medicine Units NetworkU10HD034208 · NICHD · UNIVERSITY OF UTAH · PI VARNER, MICHAEL W. · 1996 to 2015
$16.6M
NICHD Maternal Fetal Medicine Units NetworkU10HD027869 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TITA, ALAN THEVENET N. · 1991 to 2015
$12.8M
NICHD Maternal Fetal Medicine Units NetworkU10HD040485 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2001 to 2015
$12.5M
NICHD Maternal Fetal Medicine Units NetworkU10HD040560 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THORP, JOHN M · 2001 to 2015
$10.3M
NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1-TR-000439NCATS NIH HHS UL1 TR001067NCATS NIH HHS UL1 TR001070NCATS NIH HHS UL1-TR-001070NCRR NIH HHS M01 RR000034NICHD NIH HHS HD-27869NICHD NIH HHS HD-27915NICHD NIH HHS HD-34116NICHD NIH HHS HD-34208NICHD NIH HHS HD-36801NICHD NIH HHS HD-40485NICHD NIH HHS HD-40500NICHD NIH HHS HD-40512NICHD NIH HHS HD-40544NICHD NIH HHS HD-40545NICHD NIH HHS HD-40560NICHD NIH HHS HD-53097NICHD NIH HHS P2C HD050924NICHD NIH HHS U01 HD036801NICHD NIH HHS U10 HD027869NICHD NIH HHS U10 HD027915NICHD NIH HHS U10 HD034116NICHD NIH HHS U10 HD034208NICHD NIH HHS U10 HD036801NICHD NIH HHS U10 HD040485NICHD NIH HHS U10 HD040500NICHD NIH HHS U10 HD040512NICHD NIH HHS U10 HD040544NICHD NIH HHS U10 HD040545NICHD NIH HHS U10 HD040560NICHD NIH HHS U10 HD053097NICHD NIH HHS UG1 HD027869NICHD NIH HHS UG1 HD027915NICHD NIH HHS UG1 HD034116NICHD NIH HHS UG1 HD034208NICHD NIH HHS UG1 HD040485NICHD NIH HHS UG1 HD040500NICHD NIH HHS UG1 HD040512NICHD NIH HHS UG1 HD040544NICHD NIH HHS UG1 HD040545NICHD NIH HHS UG1 HD040560NICHD NIH HHS UG1 HD053097NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

objectiveTo evaluate whether treatment of mild gestational diabetes mellitus (GDM) confers sustained offspring health benefits, including a lower frequency of obesity. RESEARCH DESIGN AND

methodsFollow-up study of children (ages 5-10) of women enrolled in a multicenter trial of treatment versus no treatment of mild GDM. Height, weight, blood pressure, waist circumference, fasting glucose, fasting insulin, triglycerides, and HDL cholesterol were measured.

resultsFive hundred of 905 eligible offspring (55%) were enrolled. Maternal baseline characteristics were similar between the follow-up treated and untreated groups. The frequencies of BMI ≥95th (20.8% and 22.9%) and 85th (32.6% and 38.6%) percentiles were not significantly different in treated versus untreated offspring (P = 0.69 and P = 0.26). No associations were observed for BMI z score, log waist circumference, log triglycerides, HDL cholesterol, blood pressure, or log HOMA-estimated insulin resistance (HOMA-IR). The effect of treatment was different by sex for fasting glucose and log HOMA-IR (P for interaction = 0.002 and 0.02, respectively) but not by age-group (5-6 and 7-10 years) for any outcomes. Female offspring of treated women had significantly lower fasting glucose levels.

conclusionsAlthough treatment for mild GDM has been associated with neonatal benefits, no reduction in childhood obesity or metabolic dysfunction in the offspring of treated women was found. However, only female offspring of women treated for mild GDM had lower fasting glucose.

Indexed as

AdultBody Mass IndexBody WeightChildCholesterol, HDLDiabetes, GestationalFastingFemaleFollow-Up StudiesHealth StatusHumansInsulinInsulin ResistanceMaleObesityPregnancyCholesterol, HDLInsulinTriglycerides

Identifiers

PMID25414152
PMCPMC4338507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.