ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2015
Temporal study following burn injury in young rats is associated with skeletal muscle atrophy, inflammation and altered myogenic regulatory factors.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Protective effects of insulin treatment in the morphological alterations and oxidative damage to DNA in the liver of young rats subjected to skin scald burn injury.International journal of burns and trauma · 2025Article
- Molecular mechanisms of post-burn muscle wasting and the therapeutic potential of physical exercise.Journal of cachexia, sarcopenia and muscle · 2023Review
- C188-9, a specific inhibitor of STAT3 signaling, prevents thermal burn-induced skeletal muscle wasting in mice.Frontiers in pharmacology · 2022Article
- Consequences of ankle joint immobilisation: insights from a morphometric analysis about fibre typification, intramuscular connective tissue, and muscle spindle in rats.Histochemistry and cell biology · 2021Article
- Thermal injury initiates pervasive fibrogenesis in skeletal muscle.American journal of physiology. Cell physiology · 2020Article
- Expression levels and significance of miR-184 and miR-126 in burned rats.Experimental and therapeutic medicine · 2019Article
- Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients.Frontiers in endocrinology · 2019Article
- Experimental Periodontitis in the Potentialization of the Effects of Immobilism in the Skeletal Striated Muscle.Inflammation · 2017Article
- ER stress and subsequent activated calpain play a pivotal role in skeletal muscle wasting after severe burn injury.PloS one · 2017Article
- Article
- Satellite cell activation and apoptosis in skeletal muscle from severely burned children.The Journal of physiology · 2016Article
- Severe burn increased skeletal muscle loss in mdx mutant mice.The Journal of surgical research · 2016Article
- Skeletal muscle atrogene expression and insulin resistance in a rat model of polytrauma.Physiological reports · 2016Article
- Effects of exercise on soleus in severe burn and muscle disuse atrophy.The Journal of surgical research · 2015Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBurn injury (BI) greater than 40% has been associated with protein catabolism and it is characterized by a hypermetabolic response followed for muscle loss.
objectiveThe purpose of this study was to investigate the temporal effects of extensive experimental BI in the skeletal muscle distant from lesion, through morphological analysis, expression of genes related to muscle atrophy, inflammation and the myogenic regulatory factors. MATERIALS AND
methodsA total of 60 young male wistar rats were distributed into two groups, control (C) and subjected to scald burn injury (SBI). The animals were euthanized 1, 4 and 14 days post-sham or 45% of the total body surface BI. The medial head of gastrocnemii muscles were submitted to histopathological, morphometric (muscle fibers area and density), MyoD and myogenin immunoexpression, and gene expression for TNF-α, iNOS and E3 ubiquitin ligases (MuRF1 and MAFbx).
resultsHistopathological findings were consistent with increased amount of connective tissue and inflammatory process. Muscle fiber area of SBI groups was smaller than C and no differences were found in fiber muscle density. TNF-α was higher in SBI groups, one and 14 days post-injury; iNOS expression was higher on the first and fourth day post-injury. MuRF-1 was higher on the day four and MAFbx on the day 14.
conclusionIn conclusion, BI causes inflammation, atrophy and myogenesis stimulation in muscle as a result of systemic host response.
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