Trial reportPsychopharmacology2015
Cortisol broadens memory of a non-stressful social interaction.
Trial report in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Machine learning-based detection of acute psychosocial stress from body posture and movements.Scientific reports · 2024Article
- Social Context in Stress and Autism: Comparing Physiological Profiles Across Two Social Paradigms in Youth with and without Autism Spectrum Disorder.Research in autism spectrum disorders · 2024Article
- Modifying the Trier Social Stress Test to Induce Positive Affect.Affective science · 2021Article
- Evidence for decreased parasympathetic response to a novel peer interaction in older children with autism spectrum disorder: a case-control study.Journal of neurodevelopmental disorders · 2021Article
- Dynamic modulation of sociality and aggression: an examination of plasticity within endocrine and neuroendocrine systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Cortisol effects on fear memory reconsolidation in women.Psychopharmacology · 2016Article
- Integrated metabolomic and transcriptome analyses reveal finishing forage affects metabolic pathways related to beef quality and animal welfare.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleStress and its associated hormonal cascade are known to enhance long-term memory consolidation. Recently we have shown that central details of a stressful situation (Trier Social Stress Test; TSST) are remembered better than central details of a similar but non-stressful control condition (friendly Trier Social Stress Test; fTSST). We reasoned that since cortisol concentrations increase during stress (TSST) but remain low during the control condition (fTSST), a pharmacological increase in cortisol during the fTSST might be able to mimic the stress effects observed previously.
objectiveThe objective of the study was to assess the impact of a pharmacologically induced cortisol increase during the non-stressful friendly TSST on long-term memory for details presented during this event.
methodsIn a double-blind between-group design, participants (final sample: 20 men and 13 women) either received hydrocortisone (20 mg) or a placebo and were then exposed to a non-stressful social interaction (fTSST). Affect, salivary cortisol, and salivary alpha-amylase (sAA) were assessed before and after the fTSST. Recognition memory for objects presented during this situation was assessed 1 day later.
resultsPositive affect and sAA increased in response to the friendly TSST in both groups. Hydrocortisone enhanced memory for peripheral objects of the situation in men but not in women. Memory for central objects was not affected by the hormone.
conclusionsThe results suggest that in a non-stressful positive social environment, cortisol induces a broadening rather than a narrowing of memory. In addition, the findings provide preliminary evidence that this effect might be more prominent in men.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.