ArticleProceedings of the National Academy of Sciences of the United States of America2014
Nitric oxide regulates synaptic transmission between spiny projection neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
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- Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats.Life (Basel, Switzerland) · 2024Article
- Striatal synaptic adaptations in Parkinson's disease.Neurobiology of disease · 2022Review
- Xylazole inhibits NO-cGMP pathway in fetal rat nerve cells.Journal of veterinary science · 2022Article
- Neuronal Nitric Oxide Synthase in Nucleus Accumbens Specifically Mediates Susceptibility to Social Defeat Stress through Cyclin-Dependent Kinase 5.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson's Disease.International journal of molecular sciences · 2020Review
- Stem cell transplantation impairs dendritic cell trafficking and herpesvirus immunity.JCI insight · 2019Article
- Dopaminergic modulation of striatal function and Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Quantification of nitric oxide by high-performance liquid chromatography-fluorometric method in subgenomic hepatitis C virus-replicon expressing Huh7 cells upon treatment with acetylsalicylic acid.Experimental and therapeutic medicine · 2018Article
- Striatal synapses, circuits, and Parkinson's disease.Current opinion in neurobiology · 2018Review
- Nitric Oxide Orchestrates a Power-Law Modulation of Sympathetic Firing Behaviors in Neonatal Rat Spinal Cords.Frontiers in physiology · 2018Article
- Chitosan nanoparticles for nitric oxide delivery in human skin.MedChemComm · 2017Article
- Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses.Cell reports · 2015Article
- MeCP2 in the rostral striatum maintains local dopamine content critical for psychomotor control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Association between polymorphisms in NOS3 and KCNH2 and social memory.Frontiers in neuroscience · 2015Article
- The dependence of neuronal encoding efficiency on Hebbian plasticity and homeostatic regulation of neurotransmitter release.Frontiers in cellular neuroscience · 2015Article
Corrections and comments
- Erratum issuedCorrection.2015
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Recurrent axon collaterals are a major means of communication between spiny projection neurons (SPNs) in the striatum and profoundly affect the function of the basal ganglia. However, little is known about the molecular and cellular mechanisms that underlie this communication. We show that intrastriatal nitric oxide (NO) signaling elevates the expression of the vesicular GABA transporter (VGAT) within recurrent collaterals of SPNs. Down-regulation of striatal NO signaling resulted in an attenuation of GABAergic signaling in SPN local collaterals, down-regulation of VGAT expression in local processes of SPNs, and impaired motor behavior. PKG1 and cAMP response element-binding protein are involved in the signal transduction that transcriptionally regulates VGAT by NO. These data suggest that transcriptional control of the vesicular GABA transporter by NO regulates GABA transmission and action selection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.