ArticlePhysiological reports2014
Reduced mechanical efficiency in left-ventricular trabeculae of the spontaneously hypertensive rat.
Article in Physiological reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Danicamtiv increases cardiac mechanical efficiency.The Journal of physiology · 2025Article
- Resolving an inconsistency in the estimation of the energy for excitation of cardiac muscle contraction.Frontiers in physiology · 2023Article
- Myocardial Fatigue: a Mechano-energetic Concept in Heart Failure.Current cardiology reports · 2022Review
- Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function.The Journal of general physiology · 2021Article
- Insights From Computational Modeling Into the Contribution of Mechano-Calcium Feedback on the Cardiac End-Systolic Force-Length Relationship.Frontiers in physiology · 2020Article
- Mechanical loading of isolated cardiac muscle with a real-time computed Windkessel model of the vasculature impedance.Physiological reports · 2019Article
- Energy expenditure for isometric contractions of right and left ventricular trabeculae over a wide range of frequencies at body temperature.Scientific reports · 2019Article
- Left-Ventricular Energetics in Pulmonary Arterial Hypertension-Induced Right-Ventricular Hypertrophic Failure.Frontiers in physiology · 2017Article
- A post-MI power struggle: adaptations in cardiac power occur at the sarcomere level alongside MyBP-C and RLC phosphorylation.American journal of physiology. Heart and circulatory physiology · 2016Article
- Does reduced myocardial efficiency in systemic hypertensive-hypertrophy correlate with increased left-ventricular wall thickness?Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Long-term systemic arterial hypertension, and its associated compensatory response of left-ventricular hypertrophy, is fatal. This disease leads to cardiac failure and culminates in death. The spontaneously hypertensive rat (SHR) is an excellent animal model for studying this pathology, suffering from ventricular failure beginning at about 18 months of age. In this study, we isolated left-ventricular trabeculae from SHR-F hearts and contrasted their mechanoenergetic performance with those from nonfailing SHR (SHR-NF) and normotensive Wistar rats. Our results show that, whereas the performance of the SHR-F differed little from that of the SHR-NF, both SHR groups performed less stress-length work than that of Wistar trabeculae. Their lower work output arose from reduced ability to produce sufficient force and shortening. Neither their heat production nor their enthalpy output (the sum of work and heat), particularly the energy cost of Ca(2+) cycling, differed from that of the Wistar controls. Consequently, mechanical efficiency (the ratio of work to change of enthalpy) of both SHR groups was lower than that of the Wistar trabeculae. Our data suggest that in hypertension-induced left-ventricular hypertrophy, the mechanical performance of the tissue is compromised such that myocardial efficiency is reduced.
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