ArticlePhysiological reports2014
Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention.
Article in Physiological reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
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- Acute exercise increases syndecan-1 and -4 serum concentrations.Glycoconjugate journal · 2019Trial
- Intramyocellular lipid accumulation after sprint interval and moderate-intensity continuous training in healthy and diabetic subjects.Physiological reports · 2019Trial
- Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging.Physiological reports · 2016Trial
- Positive Effects of Physical Activity on Insulin Signaling.Current issues in molecular biology · 2024Review
- Research Progress on Lipophagy-Mediated Exercise Intervention in Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2024Review
- Effect of an acute long-duration exercise bout on skeletal muscle lipid droplet morphology, GLUT 4 protein, and perilipin protein expression.European journal of applied physiology · 2023Article
- Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity.American journal of physiology. Endocrinology and metabolism · 2023Article
- Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance.Metabolites · 2022Review
- Soluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy.Journal of molecular and cellular cardiology · 2021Article
- Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis.Molecular neurobiology · 2021Article
- Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men.Diabetologia · 2021Article
- Increasing skeletal muscle carnitine content in older individuals increases whole-body fat oxidation during moderate-intensity exercise.Aging cell · 2021Article
- Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans.Diabetologia · 2021Article
- Resveratrol-induced remodelling of myocellular lipid stores: A study in metabolically compromised humans.Physiological reports · 2021Article
- Estrogen receptor α controls metabolism in white and brown adipocytes by regulatingScience translational medicine · 2020Article
- Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle.International journal of molecular sciences · 2020Review
- Palmatine as an Agent Against Metabolic Syndrome and Its Related Complications: A Review.Drug design, development and therapy · 2020Review
- The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle.Molecular metabolism · 2019Article
- Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox.Molecular metabolism · 2018Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle lipid stores and insulin sensitivity have a recognized association although the mechanism remains unclear. We investigated how a 12-week supervised combined endurance and strength exercise intervention influenced muscle lipid stores in sedentary overweight dysglycemic subjects and normal weight control subjects (n = 18). Muscle lipid stores were measured by magnetic resonance spectroscopy (MRS), electron microscopy (EM) point counting, and direct EM lipid droplet measurements of subsarcolemmal (SS) and intramyofibrillar (IMF) regions, and indirectly, by deep sequencing and real-time PCR of mRNA of lipid droplet-associated proteins. Insulin sensitivity and VO2max increased significantly in both groups after 12 weeks of training. Muscle lipid stores were reduced according to MRS at baseline before and after the intervention, whereas EM point counting showed no change in LD stores post exercise, indicating a reduction in muscle adipocytes. Large-scale EM quantification of LD parameters of the subsarcolemmal LD population demonstrated reductions in LD density and LD diameters. Lipid droplet volume in the subsarcolemmal LD population was reduced by ~80%, in both groups, while IMF LD volume was unchanged. Interestingly, the lipid droplet diameter (n = 10 958) distribution was skewed, with a lack of small diameter lipid droplets (smaller than ~200 nm), both in the SS and IMF regions. Our results show that the SS LD lipid store was sensitive to training, whereas the dominant IMF LD lipid store was not. Thus, net muscle lipid stores can be an insufficient measure for the effects of training.
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