ArticleGenome biology2014
The genome of the sparganosis tapeworm Spirometra erinaceieuropaei isolated from the biopsy of a migrating brain lesion.
Article in Genome biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Current status, challenges and control of human sparganosis worldwide: a scoping review.Infectious diseases of poverty · 2026Article
- Gastrointestinal helminth parasites of urban and rural foxes around Melbourne, Australia.International journal for parasitology. Parasites and wildlife · 2025Article
- Discovery of new chromosomal markers through repeatome analysis of Caryophyllaeus laticeps (Caryophyllidea).Parasitology research · 2025Article
- Chromosome-Contiguous Reference Genome forInternational journal of molecular sciences · 2025Article
- Molecular identification of sparganum of Spirometra mansoni isolated from the abdominal cavity of a domestic cat in Vietnam.The Journal of veterinary medical science · 2024Article
- Lactate Dehydrogenase Gene Family inAnimals : an open access journal from MDPI · 2023Article
- Molecular Characteristics of the Fatty-Acid-Binding Protein (FABP) Family inAnimals : an open access journal from MDPI · 2023Article
- Integrated transcriptomic and proteomic analyses of plerocercoid and adult Spirometra mansoni reveal potential important pathways in the development of the medical tapeworm.Parasites & vectors · 2023Article
- Phylogenomic Analysis of 155 Helminth Species Reveals Widespread Absence of Oxygen Metabolic Capacity.Genome biology and evolution · 2023Article
- Article
- Epidemiology, Diagnosis, and Prevention of Sparganosis in Asia.Animals : an open access journal from MDPI · 2022Review
- Cestodes in the genomic era.Parasitology research · 2022Review
- Molecular Characterization and Phylogenetic Analysis ofVeterinary sciences · 2022Article
- Molecular characteristics of glutathione transferase gene family in a neglect medicalFrontiers in veterinary science · 2022Article
- Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation.Communications biology · 2021Article
- Article
- Protein phosphorylation networks in spargana of Spirometra erinaceieuropaei revealed by phosphoproteomic analysis.Parasites & vectors · 2020Article
- Evidence for densovirus integrations into tapeworm genomes.Parasites & vectors · 2019Article
- Broad tapeworms (Diphyllobothriidae), parasites of wildlife and humans: Recent progress and future challenges.International journal for parasitology. Parasites and wildlife · 2019Review
- Comparative genomics of the major parasitic worms.Nature genetics · 2019Article
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundSparganosis is an infection with a larval Diphyllobothriidea tapeworm. From a rare cerebral case presented at a clinic in the UK, DNA was recovered from a biopsy sample and used to determine the causative species as Spirometra erinaceieuropaei through sequencing of the cox1 gene. From the same DNA, we have produced a draft genome, the first of its kind for this species, and used it to perform a comparative genomics analysis and to investigate known and potential tapeworm drug targets in this tapeworm.
resultsThe 1.26 Gb draft genome of S. erinaceieuropaei is currently the largest reported for any flatworm. Through investigation of β-tubulin genes, we predict that S. erinaceieuropaei larvae are insensitive to the tapeworm drug albendazole. We find that many putative tapeworm drug targets are also present in S. erinaceieuropaei, allowing possible cross application of new drugs. In comparison to other sequenced tapeworm species we observe expansion of protease classes, and of Kuntiz-type protease inhibitors. Expanded gene families in this tapeworm also include those that are involved in processes that add post-translational diversity to the protein landscape, intracellular transport, transcriptional regulation and detoxification.
conclusionsThe S. erinaceieuropaei genome begins to give us insight into an order of tapeworms previously uncharacterized at the genome-wide level. From a single clinical case we have begun to sketch a picture of the characteristics of these organisms. Finally, our work represents a significant technological achievement as we present a draft genome sequence of a rare tapeworm, and from a small amount of starting material.
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