SynthesisMedical oncology (Northwood, London, England)2014
Circulating tumor cells in breast cancer and its association with tumor clinicopathological characteristics: a meta-analysis.
Synthesis in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Safety and Short-Term Efficacy of Irreversible Electroporation and Allogenic Natural Killer Cell Immunotherapy Combination in the Treatment of Patients with Unresectable Primary Liver Cancer.Cardiovascular and interventional radiology · 2019Trial
- The Crosstalk Between Immune Infiltration, Circulating Tumor Cells, and Metastasis in Pancreatic Cancer: Identification of HMGB3 From a Multiple Omics Analysis.Frontiers in genetics · 2022Article
- Using circulating tumor cells to evaluate the efficacy of irreversible electroporation for unresectasble pancreatic cancer.Immunologic research · 2018Article
- Effect of NK cell immunotherapy on immune function in patients with hepatic carcinoma: A preliminary clinical study.Cancer biology & therapy · 2017Article
- Analysis of circulating tumor cells in colorectal cancer liver metastasis patients before and after cryosurgery.Cancer biology & therapy · 2016Article
- Pathological complete response and prognosis after neoadjuvant chemotherapy for HER2-positive breast cancers before and after trastuzumab era: results from a real-life cohort.British journal of cancer · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to evaluate the association between tumor clinicopathological characteristics and circulating tumor cells (CTCs) in breast cancer. We searched PubMed, MEDLINE, BioMed, and EMbase databases for studies that assessed the association between tumor clinicopathological characteristics and CTCs in breast cancer. Studies obtained from search strategy were screened using pre-specified criteria, and necessary data were retrieved for meta-analysis. Fourteen studies with 2,336 patients were eligible for combined analysis. Presence of CTCs in peripheral blood (PB) was significantly associated with tumor size [OR 0.68, 95% confidence interval (CI) (0.54, 0.87), n = 10, P = 0.002], tumor grade [OR 0.71, 95% CI (0.55, 0.91), n = 8, P = 0.006], ER status [OR 0.72, 95% CI (0.57, 0.91), n = 9, P = 0.007], and PR status [OR 0.78, 95% CI (0.61, 0.98), n = 9, P = 0.04]. However, as to correlation between nodal status and CTCs presence in PB, no statistically significant difference was found [OR 0.83, 95% CI (0.67, 1.03), n = 12, P = 0.10]. The CTCs' presence in PB is correlated with tumor size, tumor grade, ER, and PR.
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Registered trials
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