Evidence map›Paper›PMID 25412864›Full record

ArticleBMJ open2014

Management of chronic neuropathic pain: a protocol for a multiple treatment comparison meta-analysis of randomised controlled trials.

Sohail M Mulla, D Norman Buckley, Dwight E Moulin, Rachel Couban, Zain Izhar, Arnav Agarwal, Akbar Panju, Li Wang, Sun Makosso Kallyth, Alparslan Turan and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Updates in the Treatment of Post-Stroke Pain.Current neurology and neuroscience reports · 2019
    Review
  3. Medicinal herbs in the treatment of neuropathic pain: a review.Iranian journal of basic medical sciences · 2018
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sohail M MullaDepartment of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada Outcomes Research Consortium, Cleveland Clinic, Cleveland, Ohio, USA.
D Norman BuckleyDepartment of Anesthesia, McMaster University, Hamilton, Ontario, Canada Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada.
Dwight E MoulinDepartments of Clinical Neurological Sciences and Oncology, Western University, London, Ontario, Canada.
Rachel CoubanMichael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada.
Zain IzharDepartment of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Arnav AgarwalDepartment of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Akbar PanjuMichael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Li WangDepartment of Anesthesia, McMaster University, Hamilton, Ontario, Canada.
Sun Makosso KallythMichael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada.
Alparslan TuranDepartment of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, USA.
Victor M MontoriKnowledge and Evaluation Research Unit, Divisions of Endocrinology and Diabetes, and Health Care & Policy Research, Mayo Clinic, Rochester, Minnesota, USA.
Daniel I SesslerDepartment of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, USA.
Lehana ThabaneDepartment of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Gordon H GuyattDepartment of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Jason W BusseDepartment of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Canadian Institutes of Health ResearchNCATS NIH HHS UL1 TR000135
6 · The paper itself

Abstract

introductionChronic neuropathic pain is associated with reduced health-related quality of life and substantial socioeconomic costs. Current research addressing management of chronic neuropathic pain is limited. No review has evaluated all interventional studies for chronic neuropathic pain, which limits attempts to make inferences regarding the relative effectiveness of treatments. METHODS AND ANALYSIS: We will conduct a systematic review of all randomised controlled trials evaluating therapies for chronic neuropathic pain. We will identify eligible trials, in any language, by a systematic search of CINAHL, EMBASE, MEDLINE, AMED, HealthSTAR, DARE, PsychINFO and the Cochrane Central Registry of Controlled Trials. Eligible trials will be: (1) enrol patients presenting with chronic neuropathic pain, and (2) randomise patients to alternative interventions (pharmacological or non-pharmacological) or an intervention and a control arm. Pairs of reviewers will, independently and in duplicate, screen titles and abstracts of identified citations, review the full texts of potentially eligible trials and extract information from eligible trials. We will use a modified Cochrane instrument to evaluate risk of bias of eligible studies, recommendations from the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) to inform the outcomes we will collect, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to evaluate our confidence in treatment effects. When possible, we will conduct: (1) in direct comparisons, a random-effects meta-analysis to establish the effect of reported therapies on patient-important outcomes; and (2) a multiple treatment comparison meta-analysis within a Bayesian framework to assess the relative effects of treatments. We will define a priori hypotheses to explain heterogeneity between studies, and conduct meta-regression and subgroup analyses consistent with the current best practices. ETHICS AND DISSEMINATION: We do not require ethics approval for our proposed review. We will disseminate our findings through peer-reviewed publications and conference presentations. TRIAL REGISTRATION NUMBER: PROSPERO (CRD42014009212).

Indexed as

Pain ManagementChronic PainHumansMeta-Analysis as TopicNeuralgiaRandomized Controlled Trials as TopicResearch DesignEPIDEMIOLOGYSTATISTICS & RESEARCH METHODS

Identifiers

PMID25412864
PMCPMC4244486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.