ArticleMalaria journal2014
A heavy legacy: offspring of malaria-infected mosquitoes show reduced disease resistance.
Article in Malaria journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Sex-dependent effects of infection on guppy reproductive fitness and offspring parasite resistance.The Journal of animal ecology · 2025Article
- Generation of specific immune memory by bacterial exposure in the major malaria vectorCurrent research in insect science · 2024Article
- The costs of transgenerational immune priming for homologous and heterologous infections with different serotypes of dengue virus inFrontiers in immunology · 2023Article
- Dengue infection modulates locomotion and host seeking in Aedes aegypti.PLoS neglected tropical diseases · 2020Article
- Chromatin changes in Anopheles gambiae induced by Plasmodium falciparum infection.Epigenetics & chromatin · 2019Article
- Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects.Frontiers in immunology · 2019Review
- Transgenerational Developmental Effects of Immune Priming in the Red Flour BeetleFrontiers in physiology · 2019Article
- Recent advances in vertebrate and invertebrate transgenerational immunity in the light of ecology and evolution.Heredity · 2018Review
- Malaria infection in mosquitoes decreases the personal protection offered by permethrin-treated bednets.Parasites & vectors · 2018Article
- Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control.Evolutionary applications · 2018Article
- Rethinking the extrinsic incubation period of malaria parasites.Parasites & vectors · 2018Review
- No evidence for manipulation of Anopheles gambiae, An. coluzzii and An. arabiensis host preference by Plasmodium falciparum.Scientific reports · 2017Article
- Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae.Scientific reports · 2017Article
- Larval nutritional stress affects vector life history traits and human malaria transmission.Scientific reports · 2016Article
- Evolution of transgenerational immunity in invertebrates.Proceedings. Biological sciences · 2016Article
- Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria.PLoS pathogens · 2016Article
- Effects of larvicidal and larval nutritional stresses on Anopheles gambiae development, survival and competence for Plasmodium falciparum.Parasites & vectors · 2016Article
- Evidence for carry-over effects of predator exposure on pathogen transmission potential.Proceedings. Biological sciences · 2015Article
- Administration of ivermectin to peridomestic cattle: a promising approach to target the residual transmission of human malaria.Malaria journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTrans-generational effects of immune stimulation may have either adaptive (trans-generational immune priming) or non-adaptive (fitness costs) effects on offspring ability to fight pathogens.
methodsAnopheles coluzzii and its natural malaria parasite Plasmodium falciparum were used to test how maternal parasite infection affected offspring resistance to the same parasite species.
resultsDaughters of exposed mothers had similar qualitative resistance, as measured by their ability to prevent infection, relative to those of control mothers. However, maternal disease exposure altered offspring quantitative resistance, measured as the ability to limit parasite development, with mosquitoes of infected mothers suffering slightly increased parasite intensity compared to controls. In addition, quantitative resistance was minimal in offspring of highly infected mothers, and in offspring issued from eggs produced during the early infection phase.
conclusionsPlasmodium falciparum infection in An. coluzzii can have trans-generational costs, lowering quantitative resistance in offspring of infected mothers. Malaria-exposed mosquitoes might heavily invest in immune defences and thereby produce lower quality offspring that are poorly resistant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.