ArticlePLoS neglected tropical diseases2014
Differential dermal expression of CCL17 and CCL18 in tuberculoid and lepromatous leprosy.
Article in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- A simple assay to quantify mycobacterial lipid antigen-specific T cell receptors in human tissues and blood.PLoS neglected tropical diseases · 2021Article
- Human macrophage polarization in the response toCurrent research in microbial sciences · 2021Article
- Insights intoProteomes · 2021Review
- A Systematic Review of Immunological Studies of Erythema Nodosum Leprosum.Frontiers in immunology · 2017Review
- Quantitative lateral flow strip assays as User-Friendly Tools To Detect Biomarker Profiles For Leprosy.Scientific reports · 2016Article
- Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist.The Journal of infectious diseases · 2016Article
- Longitudinal immune profiles in type 1 leprosy reactions in Bangladesh, Brazil, Ethiopia and Nepal.BMC infectious diseases · 2015Article
- Coming of Age--CC Chemokine Ligand 18 in ANCA-Associated Vasculitis.Journal of the American Society of Nephrology : JASN · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundLeprosy is characterized by polar clinical, histologic and immunological presentations. Previous immunologic studies of leprosy polarity were limited by the repertoire of cytokines known at the time. METHODOLOGY: We used a candidate gene approach to measure mRNA levels in skin biopsies from leprosy lesions. mRNA from 24 chemokines and cytokines, and 6 immune cell type markers were measured from 85 Nepalese leprosy subjects. Selected findings were confirmed with immunohistochemistry. PRINCIPAL
resultsExpression of three soluble mediators (CCL18, CCL17 and IL-10) and one macrophage cell type marker (CD14) was significantly elevated in lepromatous (CCL18, IL-10 and CD14) or tuberculoid (CCL17) lesions. Higher CCL18 protein expression by immunohistochemistry and a trend in increased serum CCL18 in lepromatous lesions was observed. No cytokines were associated with erythema nodosum leprosum or Type I reversal reaction following multiple comparison correction. Hierarchical clustering suggested that CCL18 was correlated with cell markers CD209 and CD14, while neither CCL17 nor CCL18 were highly correlated with classical TH1 and TH2 cytokines.
conclusionsOur findings suggest that CCL17 and CCL18 dermal expression is associated with leprosy polarity.
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Registered trials
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