ArticlePLoS neglected tropical diseases2014
Spatiotemporal transmission dynamics of hemorrhagic fever with renal syndrome in China, 2005-2012.
Article in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Small-scale spatiotemporal epidemiology of notifiable infectious diseases in China: a systematic review.BMC infectious diseases · 2022Pooled it
- Hantavirus preparedness at human-rodent interfaces: lessons from China's HFRS control and Andes virus transmission in mobile populations.Emerging microbes & infections · 2026Review
- A molecular survey of orthohantaviruses in rodents across the tri-border region of China, Russia, and North Korea.PLoS neglected tropical diseases · 2026Article
- Epidemiological characteristics and spatiotemporal heterogeneity of hemorrhagic fever with renal syndrome in the Jiaodong Peninsula region, China, 2019-2025.Frontiers in public health · 2026Article
- Influence of meteorological factors on scrub typhus in Southeast China: a study across 100 districts in Jiangxi Province.Tropical medicine and health · 2025Article
- Meteorological drivers of hemorrhagic fever with renal syndrome in China's Jiaodong Peninsula: an ecological time-series study from 2020 to 2024.Frontiers in public health · 2025Article
- Epidemiology and spatiotemporal analysis of acute hemorrhagic conjunctivitis in Zhejiang province, China (2004-2023).Frontiers in public health · 2025Article
- The 2016 Severe Floods and Incidence of Hemorrhagic Fever With Renal Syndrome in the Yangtze River Basin.JAMA network open · 2024Article
- Spatiotemporal trends of hemorrhagic fever with renal syndrome (HFRS) in China under climate variation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Time series analyses based on the joint lagged effect analysis of pollution and meteorological factors of hemorrhagic fever with renal syndrome and the construction of prediction model.PLoS neglected tropical diseases · 2023Article
- The Spatiotemporal Pattern and Its Determinants of Hemorrhagic Fever With Renal Syndrome in Northeastern China: Spatiotemporal Analysis.JMIR public health and surveillance · 2023Article
- Spatio-temporal distribution and influencing factors of norovirus outbreaks in Beijing, China from 2016 to 2020.BMC infectious diseases · 2023Article
- Epidemiological characteristics and prediction model construction of hemorrhagic fever with renal syndrome in Quzhou City, China, 2005-2022.Frontiers in public health · 2023Article
- Climate and socio-economic factors drive the spatio-temporal dynamics of HFRS in Northeastern China.One health (Amsterdam, Netherlands) · 2022Article
- Trends and focuses of hantavirus researches: a global bibliometric analysis and visualization from 1980 to 2020.Archives of public health = Archives belges de sante publique · 2022Article
- Epidemiological characteristics and spatiotemporal patterns of scrub typhus in Fujian province during 2012-2020.PLoS neglected tropical diseases · 2022Article
- Spatiotemporal association of rapid urbanization and water-body distribution on hemorrhagic fever with renal syndrome: A case study in the city of Xi'an, China.PLoS neglected tropical diseases · 2022Article
- Impact of Meteorological Factors and Southern Oscillation Index on Scrub Typhus Incidence in Guangzhou, Southern China, 2006-2018.Frontiers in medicine · 2021Article
- Investigation on risk factors of haemorrhagic fever with renal syndrome (HFRS) in Xuancheng City in Anhui Province, Mainland China.Epidemiology and infection · 2020Article
- Genetic diversity and evolution of Hantaan virus in China and its neighbors.PLoS neglected tropical diseases · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused by many serotypes of hantaviruses. In China, HFRS has been recognized as a severe public health problem with 90% of the total reported cases in the world. This study describes the spatiotemporal dynamics of HFRS cases in China and identifies the regions, time, and populations at highest risk, which could help the planning and implementation of key preventative measures.
methodsData on all reported HFRS cases at the county level from January 2005 to December 2012 were collected from Chinese Center for Disease Control and Prevention. Geographic Information System-based spatiotemporal analyses including Local Indicators of Spatial Association and Kulldorff's space-time scan statistic were performed to detect local high-risk space-time clusters of HFRS in China. In addition, cases from high-risk and low-risk counties were compared to identify significant demographic differences.
resultsA total of 100,868 cases were reported during 2005-2012 in mainland China. There were significant variations in the spatiotemporal dynamics of HFRS. HFRS cases occurred most frequently in June, November, and December. There was a significant positive spatial autocorrelation of HFRS incidence during the study periods, with Moran's I values ranging from 0.46 to 0.56 (P<0.05). Several distinct HFRS cluster areas were identified, mainly concentrated in northeastern, central, and eastern of China. Compared with cases from low-risk areas, a higher proportion of cases were younger, non-farmer, and floating residents in high-risk counties.
conclusionsThis study identified significant space-time clusters of HFRS in China during 2005-2012 indicating that preventative strategies for HFRS should be particularly focused on the northeastern, central, and eastern of China to achieve the most cost-effective outcomes.
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