ArticlePloS one2014
In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Small RNA Sequencing Reveals Dynamic Expression Profiles and Regulatory Network of miRNAs During Testis Development of Macrobrachium rosenbergii.Marine biotechnology (New York, N.Y.) · 2026Article
- TKTL1: a new candidate gene in non-obstructive azoospermia.Reproductive biomedicine online · 2025Article
- Role of Estrogen Signaling in Notch Pathway Activation in Sertoli Cells.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Article
- Dynamic transcriptomic and regulatory networks underpinning the transition from fetal primordial germ cells to spermatogonia in mice.Cell proliferation · 2025Article
- The Relationship between The Expression of SpermInternational journal of fertility & sterility · 2024Article
- Characterization of expression patterns and dynamic relocation of Notch proteins during acrosome reaction of bull spermatozoa.Scientific reports · 2024Article
- Article
- Analysis of Chromatin Openness in Testicle Tissue of Yak and Cattle-Yak.International journal of molecular sciences · 2022Article
- Dysregulation of Notch-FGF signaling axis in germ cells results in cystic dilation of the rete testis in mice.Journal of cell communication and signaling · 2022Article
- Nuclear and Membrane Receptors for Sex Steroids Are Involved in the Regulation of Delta/Serrate/LAG-2 Proteins in Rodent Sertoli Cells.International journal of molecular sciences · 2022Article
- Notch signaling in reproduction.Trends in endocrinology and metabolism: TEM · 2021Review
- Characterization of NFrontiers in cell and developmental biology · 2021Article
- Crosstalk between Androgen-ZIP9 Signaling and Notch Pathway in Rodent Sertoli Cells.International journal of molecular sciences · 2020Article
- Does Abatacept Induce Testicular Toxicity?Archives of rheumatology · 2020Article
- Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.Reproductive biology and endocrinology : RB&E · 2020Article
- miR-4270 regulates cell proliferation and apoptosis in patients with Sertoli cell-only syndrome by targeting GADD45A and inactivating the NOTCH signaling pathway.American journal of translational research · 2020Article
- The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.EMBO reports · 2019Article
- Delegating Sex: Differential Gene Expression in Stolonizing Syllids Uncovers the Hormonal Control of Reproduction.Genome biology and evolution · 2019Article
- Properties, metabolism and roles of sulfogalactosylglycerolipid in male reproduction.Progress in lipid research · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a previous study we identified active Notch signaling in key cellular events occurring at adult spermatogenesis. In this study, we evaluated the function of Notch signaling in spermatogenesis through the effects of in vivo Notch blockade. Adult CD1 male mice were either submitted to a long term DAPT (?-secretase inhibitor) or vehicle treatment. Treatment duration was designed to attain one half the time (25 days) or the time (43 days) required to accomplish a complete cycle of spermatogenesis. Blockade of Notch signaling was depicted from decreased transcription of Notch effector genes. Notch signaling blockade disrupted the expression patterns of Notch components in the testis, induced male germ cell fate aberrations, and significantly increased germ cell apoptosis, mainly in the last stages of the spermatogenic cycle, and epididymis spermatozoa morphological defects. These effects were more pronounced following the 43 day than the 25 day DAPT treatment schedule. These results indicate a relevant regulatory role of Notch signaling in mammalian spermatogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.