ArticleLymphatic research and biology2014
Radiation-induced impairment in lung lymphatic vasculature.
Article in Lymphatic research and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05081115 (The International Stress Echo Study to to Define the Future of Imaging), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The International Stress Echo Study to to Define the Future of Imaging
Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- Fluorescence tracking demonstrates T cell recirculation is transiently impaired by radiation therapy to the tumor.Scientific reports · 2024Article
- Hyperoxia Disrupts Lung Lymphatic Homeostasis in Neonatal Mice.Antioxidants (Basel, Switzerland) · 2023Article
- Biomarkers for Biodosimetry and Their Role in Predicting Radiation Injury.Cytogenetic and genome research · 2023Review
- Microarray analysis of hub genes, non-coding RNAs and pathways in lung after whole body irradiation in a mouse model.International journal of radiation biology · 2023Article
- Review
- Stress Echo 2030: The Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging.Journal of clinical medicine · 2021Article
- Lymphatic blood filling in CLEC-2-deficient mouse models.Platelets · 2021Article
- Radiation-Induced Vascular Disease-A State-of-the-Art Review.Frontiers in cardiovascular medicine · 2021Review
- Impairment of lymphatic endothelial barrier function by X-ray irradiation.International journal of radiation biology · 2019Article
- Lymphatic Function in Autoimmune Diseases.Frontiers in immunology · 2019Review
- Radiation-Induced Transformation of Immunoregulatory Networks in the Tumor Stroma.Frontiers in immunology · 2018Review
- Impact of mediastinal lymph node enlargement on the prognosis of idiopathic pulmonary fibrosis.PloS one · 2018Article
- Lymphatic Changes in Respiratory Diseases: More than Just Remodeling of the Lung?American journal of respiratory cell and molecular biology · 2017Review
- Pulmonary Vasculopathy Associated with FIGF Gene Mutation.The American journal of pathology · 2017Article
- A survey of changing trends in modelling radiation lung injury in mice: bringing out the good, the bad, and the uncertain.Laboratory investigation; a journal of technical methods and pathology · 2016Review
- Impacts of Ionizing Radiation on the Different Compartments of the Tumor Microenvironment.Frontiers in pharmacology · 2016Review
- Lymphangiogenesis and Lesion Heterogeneity in Interstitial Lung Diseases.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2015Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe lymphatic vasculature has been shown to play important roles in lung injury and repair, particularly in lung fibrosis. The effects of ionizing radiation on lung lymphatic vasculature have not been previously reported. METHODS AND
resultsC57Bl/6 mice were immobilized in a lead shield exposing only the thoracic cavity, and were irradiated with a single dose of 14 Gy. Animals were sacrificed and lungs collected at different time points (1, 4, 8, and 16 weeks) following radiation. To identify lymphatic vessels in lung tissue sections, we used antibodies that are specific for lymphatic vessel endothelial receptor 1 (LYVE-1), a marker of lymphatic endothelial cells (LEC). To evaluate LEC cell death and oxidative damage, lung tissue sections were stained for LYVE-1 and with TUNEL staining, or 8-oxo-dG respectively. Images were imported into ImageJ v1.36b and analyzed. Compared to a non-irradiated control group, we observed a durable and progressive decrease in the density, perimeter, and area of lymphatic vessels over the study period. The decline in the density of lymphatic vessels was observed in both subpleural and interstitial lymphatics. Histopathologically discernible pulmonary fibrosis was not apparent until 16 weeks after irradiation. Furthermore, there was significantly increased LEC apoptosis and oxidative damage at one week post-irradiation that persisted at 16 weeks.
conclusionsThere is impairment of lymphatic vasculature after a single dose of ionizing radiation that precedes architectural distortion and fibrosis, suggesting important roles for the lymphatic circulation in the pathogenesis of the radiation-induced lung injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.