ArticleJournal of neurotrauma2015
Long-lasting suppression of acoustic startle response after mild traumatic brain injury.
Article in Journal of neurotrauma, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Longitudinal Effects of Mild Traumatic Brain Injury on the Gut Microbiome and Acoustic Startle Response in Male and Female Rats.Journal of neurotrauma · 2026Article
- Modulation of microglia activation by the ascorbic acid transporter SVCT2.Brain, behavior, and immunity · 2024Article
- Effects of a Serotonin Receptor Peptide on Behavioral Pattern Separation in Sham- vs. Mild Traumatic Brain Injured Rats.Endocrinology, diabetes and metabolism journal · 2024Article
- Article
- Long-term increase in sensitivity to ketamine's behavioral effects in mice exposed to mild blast induced traumatic brain injury.Experimental neurology · 2022Article
- Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury.Neurotrauma reports · 2022Article
- Article
- Light-stimulus intensity modulates startle reflex habituation in larval zebrafish.Scientific reports · 2021Article
- A model-based quantification of startle reflex habituation in larval zebrafish.Scientific reports · 2021Article
- Suppressed acoustic startle response in traumatic brain injury masks post-traumatic stress disorder hyper-responsivity.Neuroreport · 2018Article
- Core-Cross-Linked Nanoparticles Reduce Neuroinflammation and Improve Outcome in a Mouse Model of Traumatic Brain Injury.ACS nano · 2017Article
- Traumatic brain injury impairs sensorimotor function in mice.The Journal of surgical research · 2017Article
- Facilitating Mitochondrial Calcium Uptake Improves Activation-Induced Cerebral Blood Flow and Behavior after mTBI.Frontiers in systems neuroscience · 2016Article
- Brain and Serum Androsterone Is Elevated in Response to Stress in Rats with Mild Traumatic Brain Injury.Frontiers in neuroscience · 2016Article
- Article
- Toll-like receptor 4 enhancement of non-NMDA synaptic currents increases dentate excitability after brain injury.Neurobiology of disease · 2015Article
- Blast Overpressure Waves Induce Transient Anxiety and Regional Changes in Cerebral Glucose Metabolism and Delayed Hyperarousal in Rats.Frontiers in neurology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Acoustic startle response (ASR) is a defensive reflex that is largely ignored unless greatly exaggerated. ASR is suppressed after moderate and severe traumatic brain injury (TBI), but the effect of mild TBI (mTBI) on ASR has not been investigated. Because the neural circuitry for ASR resides in the pons in all mammals, ASR may be a good measure of brainstem function after mTBI. The present study assessed ASR in Sprague-Dawley rats after mTBI using lateral fluid percussion and compared these effects to those on spatial working memory. mTBI caused a profound, long-lasting suppression of ASR. Both probability of emitting a startle and startle amplitude were diminished. ASR suppression was observed as soon as 1 day after injury and remained suppressed for the duration of the study (21 days after injury). No indication of recovery was observed. mTBI also impaired spatial working memory. In contrast to the suppression of ASR, working memory impairment was transient; memory was impaired 1 and 7 days after injury, but recovered by 21 days. The long-lasting suppression of ASR suggests long-term dysfunction of brainstem neural circuits at a time when forebrain neural circuits responsible for spatial working memory have recovered. These results have important implications for return-to-activity decisions because recovery of cognitive impairments plays an important role in these decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.