ArticleJournal of biophotonics2015
Low-level laser irradiation promotes the proliferation and maturation of keratinocytes during epithelial wound repair.
Article in Journal of biophotonics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Qualitative Comparison of LED and LASER Effects on Cutaneous Wound Healing: A Systematic Review of Experimental Studies.Cell biochemistry and function · 2026Pooled it
- Mechanisms of photobiomodulation therapy in treating and preventing antineoplastic-induced oral mucositis: a systematic review.Acta cirurgica brasileira · 2025Pooled it
- Should open excisions and sutured incisions be treated differently? A review and meta-analysis of animal wound models following low-level laser therapy.Lasers in medical science · 2018Pooled it
- The dark art of light measurement: accurate radiometry for low-level light therapy.Lasers in medical science · 2016Pooled it
- Effect of dual-wavelength photobiomodulation on the healing of gingival graft donor sites: a randomized controlled trial.Lasers in medical science · 2025Trial
- Biophysical skin measurements to evaluate the effectiveness of photobiomodulation therapy in the prevention of acute radiation dermatitis in breast cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Trial
- Photodynamic inactivation of Paracoccidioides brasiliensis helps the outcome of oral paracoccidiodomycosis.Lasers in medical science · 2017Trial
- Modulation of resting macrophage activity via low-level laser therapy (LLLT) and α-lipoic acid: an in vitro study using a PCL-based biomaterial.Scientific reports · 2026Article
- Article
- Multispectral Pulsed Photobiomodulation Enhances Diabetic Wound Healing via Focal Adhesion-Mediated Cell Migration and Extracellular Matrix Remodeling.International journal of molecular sciences · 2025Article
- In Vitro Effects of Low-Level Laser Therapy on the Viability and Secretory Activity of Resting Macrophages.Biomedicines · 2025Article
- Clinical Improvement and P63-Deficiency Correction in OLP Patients After Photobiomodulation.Dentistry journal · 2024Article
- Histological Improvement and Cytokine Levels Reduction in Patients with Oral Lichen Planus after Photobiomodulation Therapy.Biomedicines · 2024Article
- Effect of Infrared and Green Photomodulation Exposure on the Number of Active Myosatellite Cells in Regenerating Muscles.Bulletin of experimental biology and medicine · 2024Article
- Photobiomodulation and Wound Healing: Low-Level Laser Therapy at 661 nm in a Scratch Assay Keratinocyte Model.Annals of biomedical engineering · 2024Article
- The Role of Physical Therapies in Wound Healing and Assisted Scarring.International journal of molecular sciences · 2023Review
- Photobiomodulation Controls Keratinocytes Inflammatory Response through Nrf2 and Reduces Langerhans Cells Activation.Antioxidants (Basel, Switzerland) · 2023Article
- The effects of low power laser light at 661 nm on wound healing in a scratch assay fibroblast model.Lasers in medical science · 2022Article
- Does Photobiomodulation Affects CK10 and CK14 in Oral Mucositis Radioinduced Repair?International journal of molecular sciences · 2022Article
- Investigating the effects of low intensity visible light on human keratinocytes using a customized LED exposure system.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Low-level laser therapy (LLLT) has been extensively employed to improve epithelial wound healing, though the exact response of epithelium maturation and stratification after LLLT is unknown. Thus, this study aimed to assess the in vitro growth and differentiation of keratinocytes (KCs) and in vivo wound healing response when treated with LLLT. Human KCs (HaCaT cells) showed an enhanced proliferation with all the employed laser energy densities (3, 6 and 12 J/cm(2) , 660 nm, 100 mW), together with an increased expression of Cyclin D1. Moreover, the immunoexpression of proteins related to epithelial proliferation and maturation (p63, CK10, CK14) all indicated a faster maturation of the migrating KCs in the LLLT-treated wounds. In that way, an improved epithelial healing was promoted by LLLT with the employed parameters; this improvement was confirmed by changes in the expression of several proteins related to epithelial proliferation and maturation. Immunofluorescent expression of cytokeratin 10 (red) and Cyclin D1 (green) in (A) Control keratinocytes and (B) Low-level laser irradiated cells. Blue color illustrates the nuclei of the cells (DAPI staining).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.