ArticlePloS one2014
Comparative genomics of transcriptional regulation of methionine metabolism in Proteobacteria.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Cross-regulation of amino acid synthesis and anaerobic electron transfer by MetR-mediated methionine signaling.Journal of bacteriology · 2026Article
- Sulfoquinovose Catabolism inInternational journal of molecular sciences · 2025Article
- Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization bymSphere · 2025Article
- Genome-wide phenotypic profiling of transcription factors and identification of novel targets to control the virulence of Vibrio vulnificus.Nucleic acids research · 2025Article
- Transcriptomic and Metabolomic Insights Into the Prebiotic Potential of Camellia Seed Oil for EnhancingFood science & nutrition · 2025Article
- Transcriptional Control ofApplied and environmental microbiology · 2023Article
- Genomics-Based Reconstruction and Predictive Profiling of Amino Acid Biosynthesis in the Human Gut Microbiome.Microorganisms · 2022Article
- Small Noncoding RNA CjNC110 Influences Motility, Autoagglutination, AI-2 Localization, Hydrogen Peroxide Sensitivity, and Chicken Colonization in Campylobacter jejuni.Infection and immunity · 2020Article
- A SAM-I riboswitch with the ability to sense and respond to uncharged initiator tRNA.Nature communications · 2020Article
- Unraveling the role of quorum sensing-dependent metabolic homeostasis of the activated methyl cycle in a cooperative population of Burkholderia glumae.Scientific reports · 2019Article
- The rsmS (ybaM) mutation causes bypass suppression of the RsmAB post-transcriptional virulence regulation system in enterobacterial phytopathogens.Scientific reports · 2019Article
- The Gram-negative phytopathogen Xanthomonas campestris pv. campestris employs a 5'UTR as a feedback controller to regulate methionine biosynthesis.Microbiology (Reading, England) · 2018Article
- Riboswitch diversity and distribution.RNA (New York, N.Y.) · 2017Article
- Using RNA Sequence and Structure for the Prediction of Riboswitch Aptamer: A Comprehensive Review of Available Software and Tools.Frontiers in genetics · 2017Review
- Comparative genomics and evolution of transcriptional regulons inMicrobial genomics · 2016Article
- Structural basis for DNA recognition by the transcription regulator MetR.Acta crystallographica. Section F, Structural biology communications · 2016Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methionine metabolism and uptake genes in Proteobacteria are controlled by a variety of RNA and DNA regulatory systems. We have applied comparative genomics to reconstruct regulons for three known transcription factors, MetJ, MetR, and SahR, and three known riboswitch motifs, SAH, SAM-SAH, and SAM_alpha, in ∼ 200 genomes from 22 taxonomic groups of Proteobacteria. We also identified two novel regulons: a SahR-like transcription factor SamR controlling various methionine biosynthesis genes in the Xanthomonadales group, and a potential RNA regulatory element with terminator-antiterminator mechanism controlling the metX or metZ genes in beta-proteobacteria. For each analyzed regulator we identified the core, taxon-specific and genome-specific regulon members. By analyzing the distribution of these regulators in bacterial genomes and by comparing their regulon contents we elucidated possible evolutionary scenarios for the regulation of the methionine metabolism genes in Proteobacteria.
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