Trial reportJournal of clinical microbiology1989
Reactions to and antigenicity of two human-rhesus rotavirus reassortant vaccine candidates of serotypes 1 and 2 in Venezuelan infants.
Trial report in Journal of clinical microbiology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Rotavirus vaccine for preventing diarrhoea.The Cochrane database of systematic reviews · 2004Pooled it
- Human rotavirus vaccine Rotarix™ provides protection against diverse circulating rotavirus strains in African infants: a randomized controlled trial.BMC infectious diseases · 2012Trial
- Immunogenicity, safety and efficacy of tetravalent rhesus-human, reassortant rotavirus vaccine in Belém, Brazil.Bulletin of the World Health Organization · 1996Trial
- Reactogenicity and immunogenicity of a high-titer rhesus rotavirus-based quadrivalent rotavirus vaccine.Journal of clinical microbiology · 1993Trial
- Serum-neutralizing antibody to VP4 and VP7 proteins in infants following vaccination with WC3 bovine rotavirus.Journal of virology · 1990Trial
- Clinical studies of a quadrivalent rotavirus vaccine in Venezuelan infants.Journal of clinical microbiology · 1990Trial
- Comparison of immunoglobulin A (IgA), IgG, and IgM enzyme-linked immunosorbent assays, plaque reduction neutralization assay, and complement fixation in detecting seroresponses to rotavirus vaccine candidates.Journal of clinical microbiology · 1989Trial
- Overview of the Development, Impacts, and Challenges of Live-Attenuated Oral Rotavirus Vaccines.Vaccines · 2020Review
- Effects of maternal antibodies on protection and development of antibody responses to human rotavirus in gnotobiotic pigs.Journal of virology · 1999Article
- Quantification of systemic and local immune responses to individual rotavirus proteins during rotavirus infection in mice.Journal of clinical microbiology · 1996Article
- Rotavirus vaccines: an overview.Clinical microbiology reviews · 1996Review
- Geographic distribution of human rotavirus VP4 genotypes and VP7 serotypes in five South African regions.Journal of clinical microbiology · 1995Article
- Selection of cold-adapted mutants of human rotaviruses that exhibit various degrees of growth restriction in vitro.Journal of virology · 1994Article
- Rotaviruses: immunological determinants of protection against infection and disease.Advances in virus research · 1994Review
- Distribution of VP4 gene alleles in human rotaviruses by using probes to the hyperdivergent region of the VP4 gene.Journal of clinical microbiology · 1993Article
- Analysis of homotypic and heterotypic serum immune responses to rotavirus proteins following primary rotavirus infection by using the radioimmunoprecipitation technique.Journal of clinical microbiology · 1993Article
- Antibodies to seven rotavirus serotypes in cord sera, maternal sera, and colostrum of German women.Journal of clinical microbiology · 1991Article
- Homotypic and heterotypic serological responses to rotavirus neutralization epitopes in immunologically naive and experienced animals.Journal of clinical microbiology · 1991Article
- Serologic and mucosal immune response to rotavirus infection in the rabbit model.Journal of virology · 1991Article
- Operational overlapping of cross-reactive and serotype-specific neutralization epitopes on VP7 of human rotavirus serotype 3.Archives of virology · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reactions to and antigenicity of two human-rhesus rotavirus (RRV) reassortants (human rotavirus strain D x RRV and human rotavirus strain DS1 x RRV) with the VP7 neutralization specificity of a serotype 1 or serotype 2 rotavirus were evaluated in a placebo-controlled double-blind trial in 116 1- to 5-month-old infants in Caracas, Venezuela. The children were randomly divided into five groups to receive orally the following inocula: (i) 10(4) PFU of D x RRV reassortant; (ii) 10(4) PFU of DS1 x RRV reassortant; (iii) 10(4) PFU of RRV; (iv) 5 x 10(3) PFU of D x RRV and 5 x 10(3) PFU of RRV; and (v) placebo. The children were examined daily for 7 days following vaccine administration; 8 to 26% of the vaccinated infants developed a mild febrile reaction which in most cases lasted only 1 day. Seroresponses to rotavirus were observed in 39 to 65% of the vaccinees by plaque neutralization assay and in 57 to 88% by an immunoglobulin A enzyme-linked immunosorbent assay. Vaccine shedding was detected in 53 to 86% of the vaccinees. Analysis of neutralization antibody responses indicates that the VP4 protein represents an important component of the response induced by the vaccines.
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