ReviewJournal of diabetes investigation2014
Modeling type 2 diabetes in rats using high fat diet and streptozotocin.
Review in Journal of diabetes investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 250 papers, 1 of them a synthesis that pooled it.
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Who cites it
250 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antioxidant and anti-inflammatory properties of ginsenoside Rg1 for hyperglycemia in type 2 diabetes mellitus: systematic reviews and meta-analyses of animal studies.Frontiers in pharmacology · 2023Pooled it
- Polyphenol-Rich Mangosteen Pericarp Extract Attenuates Metabolic and Reproductive Dysfunction in High-fat Diet and Streptozotocin-induced Obese-Diabetic Male Rats: A Preliminary Study.Applied biochemistry and biotechnology · 2026Article
- Combined respiratory muscle training and photobiomodulation improve systemic and tissue-specific redox homeostasis in a rat model of type 2 diabetes.Acta diabetologica · 2026Article
- Epicatechin and High-Molecular Weight Fraction Do Not Recapitulate the Antiobesity and Antidiabetes Activities of Whole Cocoa Extract.Journal of agricultural and food chemistry · 2026Article
- Low-frequency electroacupuncture attenuates insulin resistance in a rat model of diet-induced maternal obesity.Pregnancy (Hoboken, N.J.) · 2026Article
- Reversal of diabetes-associated cognitive impairment through modulation of BDNF, insulin, and NF-κB pathways by a marketed herbal formulation.3 Biotech · 2026Article
- Zinc Potentiates the Renoprotective Effects of SGLT2 Inhibitors in Experimental Diabetes Mellitus in Rats.Life (Basel, Switzerland) · 2026Article
- Single-cell insights into maladaptive endothelial plasticity and therapeutic targets in diabetic vascular complications.Cardiovascular diabetology · 2026Review
- Docosahexaenoic acid is comparable to vildagliptin in improving hyperglycemia and pancreatic insulin signaling of diabetic rats via SIRT1/Akt/PI3K pathway.Scientific reports · 2026Article
- Respiratory muscle training attenuates oxidative stress and improves antioxidant activity in diabetic rats induced by high-fat diet and low-dose streptozotocin.European journal of applied physiology · 2026Article
- Duodenal myoelectrical hyperactivity drives diabetic remission in rat models of type 2 diabetes.Diabetologia · 2026Article
- Propolis alleviates brain tissue damage and oxidative abnormalities in streptozotocin (STZ)-induced diabetes.Journal, genetic engineering & biotechnology · 2026Article
- Distinct immunometabolic signatures of type 1 versus type 2 diabetes in a murine model of myocardial infarction.Cardiovascular diabetology · 2026Article
- Renoprotection by 5-Methoxytryptophan in Kidney Disease.Biomolecules · 2026Review
- Impact of PKC-MAPK Signaling on Cardiac Sympathetic Overactivation in Type-2 Diabetes Mellitus.International journal of molecular sciences · 2026Article
- Prolonged Somatostatin Receptor 2 Antagonism Enhances Glucagon Response to Hypoglycemia in Male Diabetic Rats.Endocrinology · 2026Article
- Molecular mechanisms of Buyang Huanwu Decoction in improving Diabetic kidney disease based on network pharmacology and experimental validation.American journal of translational research · 2026Article
- Type 2 Diabetes Impairs Alveolar Socket Healing: Immunohistochemical Analysis of Del-1, IL-17, RANKL, and OPG Expression in a Rat Model.International journal of dentistry · 2026Article
- Role of the xenobiotic-activated pregnane X receptor in type 1 and type 2 diabetes in male mice.Biochemical pharmacology · 2026Article
- Article
190 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathology of type 2 diabetes is complex, with multiple stages culminating in a functional β-cell mass that is insufficient to meet the body's needs. Although the broad outlines of the disease etiology are known, many critical questions remain to be answered before next-generation therapeutics can be developed. In order to further elucidate the pathobiology of this disease, animal models mimicking the pathology of human type 2 diabetes are of great value. One example of a type 2 diabetes animal model is the high-fat diet-fed, streptozotocin (HFD/STZ)-treated rat model. The present review first summarizes the current understanding of the metabolic profile and pathology involved in the different stages of the type 2 diabetes disease progression in humans. Second, the known characteristics of the HFD/STZ rat model are reviewed and compared with the pathophysiology of human type 2 diabetes. Next, the suitability of the HFD/STZ model as a model of type 2 diabetes with a focus on identifying critical caveats and unanswered questions about the model is discussed. The improved understanding of refined animal models will hopefully lead to more relevant preclinical studies and development of improved therapeutics for diabetes. Depending on the amount of residual functional β-cells mass, the HFD/STZ rat model might be a suitable animal model of the final stage of type 2 diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.