ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Pathway-selective adjustment of prefrontal-amygdala transmission during fear encoding.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional neuroimaging in patients with catatonia: A systematic review.Journal of psychosomatic research · 2024Pooled it
- Ventral and Intermediate Hippocampus Are Required for Object-in-Place Recognition Memory in Mice.eNeuro · 2026Article
- Learning, sleep replay and consolidation of contextual fear memories: A neural network model.PLoS computational biology · 2026Article
- Analysis of Prefrontal-Amygdala Synaptic Functions Using Optogenetics and Patch-Clamp Recording.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Medial prefrontal cortex circuit dynamics involved in stage-specific addiction.Brain structure & function · 2025Review
- The prelimbic prefrontal cortex mediates the development of lasting social avoidance as a consequence of social threat conditioning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Impaired Synaptic Activity in the Basolateral Amygdala Is Associated With an Alcohol Use Disorder-Like Vulnerable Phenotype in Male Rats.Addiction biology · 2025Article
- Endocannabinoid interference blocks post-global cerebral ischemia depression through prefrontal cortico-amygdala projections.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Infralimbic Projections to the Substantia Innominata-Ventral Pallidum Constrain Defensive Behavior during Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Developmentally distinct architectures in top-down pathways controlling threat avoidance.Nature neuroscience · 2025Article
- The Role of Basolateral Amygdala and Medial Prefrontal Cortex in Fear: A Systematic Review.Cureus · 2025Review
- Early postnatal exposure to bicuculline modulates E/I balance and induces ASD-like behavioral phenotypes in mice.Animal cells and systems · 2025Article
- Synaptic acetylcholine induces sharp wave ripples in the basolateral amygdala through nicotinic receptors.bioRxiv : the preprint server for biology · 2024Article
- Sex differences in contextual fear expression are associated with altered medial prefrontal cortex activity.bioRxiv : the preprint server for biology · 2024Article
- Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice.Current biology : CB · 2024Article
- Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Subregion preference in the long-range connectome of pyramidal neurons in the medial prefrontal cortex.BMC biology · 2024Article
- Neuronal tuning to threat exposure remains stable in the mouse prefrontal cortex over multiple days.PLoS biology · 2024Article
- Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice.bioRxiv : the preprint server for biology · 2023Article
- Pre- and postsynaptic N-methyl-D-aspartate receptors are required for sequential printing of fear memory engrams.iScience · 2023Article
17 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
Conditioned fear requires neural activity in the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC), structures that are densely interconnected at the synaptic level. Previous work has suggested that anatomical subdivisions of mPFC make distinct contributions to fear expression and inhibition, and that the functional output of this processing is relayed to the BLA complex. However, it remains unknown whether synaptic plasticity in mPFC-BLA networks contributes to fear memory encoding. Here we use optogenetics and ex vivo electrophysiology to reveal the impact of fear conditioning on BLA excitatory and feedforward inhibitory circuits formed by projections from infralimbic (IL) and prelimbic (PL) cortices. In naive mice, these pathways recruit equivalent excitation and feedforward inhibition in BLA principal neurons. However, fear learning leads to a selective decrease in inhibition:excitation balance in PL circuits that is attributable to a postsynaptic increase in AMPA receptor function. These data suggest a pathway-specific mechanism for fear memory encoding by adjustment of mPFC-BLA transmission. Upon reengagement of PL by conditioned cues, these modifications may serve to amplify emotional responses.
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