ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
The neural circuit mechanisms underlying the retinal response to motion reversal.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Distinct inhibitory connectivity motifs could trigger distinct forms of anticipation in the retinal network.Scientific reports · 2026Article
- Filter-based models of suppression in retinal ganglion cells: Comparison and generalization across species and stimuli.PLoS computational biology · 2025Article
- Stimulus-invariant aspects of the retinal code drive discriminability of natural scenes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells.Nature communications · 2022Article
- Novel stimuli evoke excess activity in the mouse primary visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Delayed Correction for Extrapolation in Amblyopia.Investigative ophthalmology & visual science · 2021Article
- Remembering the Past to See the Future.Annual review of vision science · 2021Article
- What the salamander eye has been telling the vision scientist's brain.Seminars in cell & developmental biology · 2020Review
- Clustering of Neural Activity: A Design Principle for Population Codes.Frontiers in computational neuroscience · 2020Article
- From deep learning to mechanistic understanding in neuroscience: the structure of retinal prediction.Advances in neural information processing systems · 2019Article
- Unusual Physiological Properties of Smooth Monostratified Ganglion Cell Types in Primate Retina.Neuron · 2019Article
- The dynamic receptive fields of retinal ganglion cells.Progress in retinal and eye research · 2018Review
- Diversity in spatial scope of contrast adaptation among mouse retinal ganglion cells.Journal of neurophysiology · 2017Article
- Article
- Article
- Three Small-Receptive-Field Ganglion Cells in the Mouse Retina Are Distinctly Tuned to Size, Speed, and Object Motion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The oscillation-like activity in bullfrog ON-OFF retinal ganglion cell.Cognitive neurodynamics · 2016Article
- Joint Encoding of Object Motion and Motion Direction in the Salamander Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Error-Robust Modes of the Retinal Population Code.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
To make up for delays in visual processing, retinal circuitry effectively predicts that a moving object will continue moving in a straight line, allowing retinal ganglion cells to anticipate the object's position. However, a sudden reversal of motion triggers a synchronous burst of firing from a large group of ganglion cells, possibly signaling a violation of the retina's motion prediction. To investigate the neural circuitry underlying this response, we used a combination of multielectrode array and whole-cell patch recordings to measure the responses of individual retinal ganglion cells in the tiger salamander to reversing stimuli. We found that different populations of ganglion cells were responsible for responding to the reversal of different kinds of objects, such as bright versus dark objects. Using pharmacology and designed stimuli, we concluded that ON and OFF bipolar cells both contributed to the reversal response, but that amacrine cells had, at best, a minor role. This allowed us to formulate an adaptive cascade model (ACM), similar to the one previously used to describe ganglion cell responses to motion onset. By incorporating the ON pathway into the ACM, we were able to reproduce the time-varying firing rate of fast OFF ganglion cells for all experimentally tested stimuli. Analysis of the ACM demonstrates that bipolar cell gain control is primarily responsible for generating the synchronized retinal response, as individual bipolar cells require a constant time delay before recovering from gain control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.