ArticleJournal of neurophysiology2015
Serotonin differentially modulates Ca2+ transients and depolarization in a C. elegans nociceptor.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Positive interaction between ASH and ASK sensory neurons accelerates nociception and inhibits behavioral adaptation.iScience · 2022Article
- Reduced CaFrontiers in neuroscience · 2022Article
- Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- Calcium Imaging of Neuronal Activity under Gradually Changing Odor Stimulation inBio-protocol · 2021Article
- Regulation of the Serotonergic System by Kainate in the Avian Retina.Cellular and molecular neurobiology · 2019Article
- Sensorimotor integration inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- The extraordinary AFD thermosensor of C. elegans.Pflugers Archiv : European journal of physiology · 2018Review
- A Single-Neuron Chemosensory Switch Determines the Valence of a Sexually Dimorphic Sensory Behavior.Current biology : CB · 2018Article
- Serotonin Disinhibits aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- "Getting Under the Hood" of Neuronal Signaling inJournal of experimental neuroscience · 2018Article
- A mathematical and computational model of the calcium dynamics in Caenorhabditis elegans ASH sensory neuron.PloS one · 2018Article
- Diverse modes of synaptic signaling, regulation, and plasticity distinguish two classes ofeLife · 2017Article
- Article
- Multisensory integration in C. elegans.Current opinion in neurobiology · 2017Review
- Cannabinoids Activate Monoaminergic Signaling to Modulate KeyThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Chemically induced oxidative stress affects ASH neuronal function and behavior in C. elegans.Scientific reports · 2016Article
- Opiates Modulate Noxious Chemical Nociception through a Complex Monoaminergic/Peptidergic Cascade.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Multiple Sensory Inputs Are Extensively Integrated to Modulate Nociception in C. elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Monoamines and neuropeptides modulate neuronal excitability and synaptic strengths, shaping circuit activity to optimize behavioral output. In C. elegans, a pair of bipolar polymodal nociceptors, the ASHs, sense 1-octanol to initiate escape responses. In the present study, 1-octanol stimulated large increases in ASH Ca(2+), mediated by L-type voltage-gated Ca(2+) channels (VGCCs) in the cell soma and L-plus P/Q-type VGCCs in the axon, which were further amplified by Ca(2+) released from intracellular stores. Importantly, 1-octanol-dependent aversive responses were not inhibited by reducing ASH L-VGCC activity genetically or pharmacologically. Serotonin, an enhancer of 1-octanol avoidance, potentiated 1-octanol-dependent ASH depolarization measured electrophysiologically, but surprisingly, decreased the ASH somal Ca(2+) transients. These results suggest that ASH somal Ca(2+) transient amplitudes may not always be predictive of neuronal depolarization and synaptic output. Therefore, although increases in steady-state Ca(2+) can reliably indicate when neurons become active, quantitative relationships between Ca(2+) transient amplitudes and neuronal activity may not be as straightforward as previously anticipated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.