ArticleAmerican journal of physiology. Cell physiology2015
The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation.
Article in American journal of physiology. Cell physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Automatic classification of circulating blood cell clusters based on multi-channel flow cytometry imaging.Engineering applications of artificial intelligence · 2026Article
- Circulating tumor cells and circulating tumor microemboli: role in venous thromboembolism in oncologic patients.Bioscience reports · 2026Review
- Automatic Classification of Circulating Blood Cell Clusters based on Multi-channel Flow Cytometry Imaging.bioRxiv : the preprint server for biology · 2025Article
- Appendiceal cancer in pregnancy and circulating tumor cells detection in the umbilical cord.Heliyon · 2025Article
- Stress in the metastatic journey - the role of cell communication and clustering in breast cancer progression and treatment resistance.Disease models & mechanisms · 2024Article
- Review
- How circulating tumor cluster biology contributes to the metastatic cascade: from invasion to dissemination and dormancy.Cancer metastasis reviews · 2023Review
- Antiplatelet Therapy Combined with Anastrozole Induces Features of Partial EMT in Breast Cancer Cells and Fails to Mitigate Breast-Cancer Induced Hypercoagulation.International journal of molecular sciences · 2021Article
- Article
- Investigating the Interaction Between Circulating Tumor Cells and Local HydrodynamicsCellular and molecular bioengineering · 2020Article
- Fluids and their mechanics in tumour transit: shaping metastasis.Nature reviews. Cancer · 2020Review
- Effect of circulating tumor cell aggregate configuration on hemodynamic transport and wall contact.Mathematical biosciences · 2017Article
- Platelet count as a predictor of metastasis and venous thromboembolism in patients with cancer.Convergent science physical oncology · 2017Article
- Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC.American journal of physiology. Cell physiology · 2017Article
- Circulating Tumor Cells: Fluid Surrogates of Solid Tumors.Annual review of pathology · 2017Review
- Circulating tumor cell clusters: What we know and what we expect (Review).International journal of oncology · 2016Review
- Cancer and Thrombosis: The Platelet Perspective.Frontiers in cell and developmental biology · 2016Review
- The prothrombotic activity of cancer cells in the circulation.Blood reviews · 2016Review
- The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint.Journal of oncology · 2016Article
- Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment.Advances in experimental medicine and biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Thrombotic events can herald the diagnosis of cancer, preceding any cancer-related clinical symptoms. Patients with cancer are at a 4- to 7-fold increased risk of suffering from venous thromboembolism (VTE), with ∼7,000 patients with lung cancer presenting from VTEs. However, the physical biology underlying cancer-associated VTE remains poorly understood. Several lines of evidence suggest that the shedding of tissue factor (TF)-positive circulating tumor cells (CTCs) and microparticles from primary tumors may serve as a trigger for cancer-associated thrombosis. To investigate the potential direct and indirect roles of CTCs in VTE, we characterized thrombin generation by CTCs in an interactive numerical model coupling blood flow with advection-diffusion kinetics. Geometric measurements of CTCs isolated from the peripheral blood of a lung cancer patient prior to undergoing lobectomy formed the basis of the simulations. Singlet, doublet, and aggregate circulating tumor microemboli (CTM) were investigated in the model. Our numerical model demonstrated that CTM could potentiate occlusive events that drastically reduce blood flow and serve as a platform for the promotion of thrombin generation in flowing blood. These results provide a characterization of CTM dynamics in the vasculature and demonstrate an integrative framework combining clinical, biophysical, and mathematical approaches to enhance our understanding of CTCs and their potential direct and indirect roles in VTE formation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.