ArticleThe American journal of clinical nutrition2014
Preconception serum 1,1,1-trichloro-2,2,bis(p-chlorophenyl)ethane and B-vitamin status: independent and joint effects on women's reproductive outcomes.
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Article in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 19 citations in OpenAlex.
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- The Association between Long-Term DDT or DDE Exposures and an Altered Sperm Epigenome-a Cross-Sectional Study of Greenlandic Inuit and South African VhaVenda Men.Environmental health perspectives · 2024Article
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- Contrasting Association of Maternal Plasma Biomarkers of Smoking and 1-Carbon Micronutrients with Offspring DNA Methylation: Evidence of Aryl Hydrocarbon Receptor Repressor Gene-Smoking-Folate Interaction.The Journal of nutrition · 2023Article
- In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals.International journal of obesity (2005) · 2022Observational
- Healthy diet during pregnancy-navigating the double-edged sword.The American journal of clinical nutrition · 2021Article
- In utero exposure to mercury and childhood overweight or obesity: counteracting effect of maternal folate status.BMC medicine · 2019Article
- Supplemental Folate and the Relationship Between Traffic-Related Air Pollution and Livebirth Among Women Undergoing Assisted Reproduction.American journal of epidemiology · 2019Article
- Invited Commentary: Interaction Between Diet and Chemical Exposures.American journal of epidemiology · 2019Article
- Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2018Article
- Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder.Environmental health perspectives · 2017Article
- Association Between Maternal Prepregnancy Body Mass Index and Plasma Folate Concentrations With Child Metabolic Health.JAMA pediatrics · 2016Article
- Intake of Fruits and Vegetables with Low-to-Moderate Pesticide Residues Is Positively Associated with Semen-Quality Parameters among Young Healthy Men.The Journal of nutrition · 2016Article
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Authors and funding
10 authors at 2 institutions in 4 countries.
Fengxiu OuyangFrom the Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (FO); the Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC (MPL); the Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada (SAV); the Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (SJ and XW); the Department of Environmental Health, Harvard School of Public Health, Boston, MA (SK); the Shanghai Jiaotong University School of Public Health, Shanghai, China (JZ); the National Clinical Research Center of Kidney Disease; State Key Laboratory of Organ Failure Research; Nanfang Hospital, Southern Medical University, Guangzhou, China (XX); and the Departments of International Health (PC) and Biostatistics (M-CW) and Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health (XW), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Matthew P LongneckerFrom the Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (FO); the Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC (MPL); the Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada (SAV); the Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (SJ and XW); the Department of Environmental Health, Harvard School of Public Health, Boston, MA (SK); the Shanghai Jiaotong University School of Public Health, Shanghai, China (JZ); the National Clinical Research Center of Kidney Disease; State Key Laboratory of Organ Failure Research; Nanfang Hospital, Southern Medical University, Guangzhou, China (XX); and the Departments of International Health (PC) and Biostatistics (M-CW) and Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health (XW), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Scott A VennersFrom the Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (FO); the Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC (MPL); the Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada (SAV); the Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (SJ and XW); the Department of Environmental Health, Harvard School of Public Health, Boston, MA (SK); the Shanghai Jiaotong University School of Public Health, Shanghai, China (JZ); the National Clinical Research Center of Kidney Disease; State Key Laboratory of Organ Failure Research; Nanfang Hospital, Southern Medical University, Guangzhou, China (XX); and the Departments of International Health (PC) and Biostatistics (M-CW) and Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health (XW), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Sara JohnsonFrom the Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (FO); the Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC (MPL); the Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada (SAV); the Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (SJ and XW); the Department of Environmental Health, Harvard School of Public Health, Boston, MA (SK); the Shanghai Jiaotong University School of Public Health, Shanghai, China (JZ); the National Clinical Research Center of Kidney Disease; State Key Laboratory of Organ Failure Research; Nanfang Hospital, Southern Medical University, Guangzhou, China (XX); and the Departments of International Health (PC) and Biostatistics (M-CW) and Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health (XW), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Susan KorrickFrom the Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (FO); the Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC (MPL); the Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada (SAV); the Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (SJ and XW); the Department of Environmental Health, Harvard School of Public Health, Boston, MA (SK); the Shanghai Jiaotong University School of Public Health, Shanghai, China (JZ); the National Clinical Research Center of Kidney Disease; State Key Laboratory of Organ Failure Research; Nanfang Hospital, Southern Medical University, Guangzhou, China (XX); and the Departments of International Health (PC) and Biostatistics (M-CW) and Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health (XW), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Jun ZhangFrom the Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (FO); the Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC (MPL); the Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada (SAV); the Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (SJ and XW); the Department of Environmental Health, Harvard School of Public Health, Boston, MA (SK); the Shanghai Jiaotong University School of Public Health, Shanghai, China (JZ); the National Clinical Research Center of Kidney Disease; State Key Laboratory of Organ Failure Research; Nanfang Hospital, Southern Medical University, Guangzhou, China (XX); and the Departments of International Health (PC) and Biostatistics (M-CW) and Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health (XW), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Xiping XuFrom the Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (FO); the Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC (MPL); the Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada (SAV); the Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (SJ and XW); the Department of Environmental Health, Harvard School of Public Health, Boston, MA (SK); the Shanghai Jiaotong University School of Public Health, Shanghai, China (JZ); the National Clinical Research Center of Kidney Disease; State Key Laboratory of Organ Failure Research; Nanfang Hospital, Southern Medical University, Guangzhou, China (XX); and the Departments of International Health (PC) and Biostatistics (M-CW) and Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health (XW), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Parul ChristianFrom the Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (FO); the Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC (MPL); the Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada (SAV); the Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (SJ and XW); the Department of Environmental Health, Harvard School of Public Health, Boston, MA (SK); the Shanghai Jiaotong University School of Public Health, Shanghai, China (JZ); the National Clinical Research Center of Kidney Disease; State Key Laboratory of Organ Failure Research; Nanfang Hospital, Southern Medical University, Guangzhou, China (XX); and the Departments of International Health (PC) and Biostatistics (M-CW) and Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health (XW), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Mei-Cheng WangFrom the Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (FO); the Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC (MPL); the Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada (SAV); the Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (SJ and XW); the Department of Environmental Health, Harvard School of Public Health, Boston, MA (SK); the Shanghai Jiaotong University School of Public Health, Shanghai, China (JZ); the National Clinical Research Center of Kidney Disease; State Key Laboratory of Organ Failure Research; Nanfang Hospital, Southern Medical University, Guangzhou, China (XX); and the Departments of International Health (PC) and Biostatistics (M-CW) and Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health (XW), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Xiaobin WangFrom the Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (FO); the Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC (MPL); the Simon Fraser University, Faculty of Health Sciences, Burnaby, Canada (SAV); the Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (SJ and XW); the Department of Environmental Health, Harvard School of Public Health, Boston, MA (SK); the Shanghai Jiaotong University School of Public Health, Shanghai, China (JZ); the National Clinical Research Center of Kidney Disease; State Key Laboratory of Organ Failure Research; Nanfang Hospital, Southern Medical University, Guangzhou, China (XX); and the Departments of International Health (PC) and Biostatistics (M-CW) and Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health (XW), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Johns Hopkins University · USNational Institutes of Health · US
Funding
Human Health Effects Of Exposure To Organochlorine CompoundsZIAES049016 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONGNECKER, MATTHEW · 2009 to 2015
$1.0MDDT, Endocrine Disruption and Reproductive OutcomesR01ES011682 · NIEHS · CHILDREN'S MEMORIAL HOSPITAL (CHICAGO) · PI WANG, XIAOBIN · 2001 to 2003
$926kROTATING SHIFTWORK AND REPRODUCTIVE OUTCOMESR01HD032505 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI XU, XIPING X · 1996 to 2000
$307kPreconception Nutrition, Endocrine Disruptors, Reproductive OutcomesR03ES022790 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI WANG, XIAOBIN · 2013 to 2014
$161kIntramural NIH HHSNICHD NIH HHS R01 HD32505NIEHS NIH HHS R01 ES11682NIEHS NIH HHS R03 ES022790
Abstract
backgroundAlthough preconception 1,1,1-trichloro-2,2,bis(p-chlorophenyl)ethane (DDT) exposure and B-vitamin deficiencies have each been shown to negatively affect human reproductive outcomes, little is known about their joint effect.
objectiveWe sought to examine whether B-vitamin sufficiency protects against adverse effects of DDT on clinical pregnancy (CP) and subclinical early pregnancy loss (EPL).
designWe measured preconception concentrations of plasma B vitamins (vitamin B-6, vitamin B-12, and folate) and serum total DDT [sum of p,p' and o,p' isomers of DDT and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene] in 291 nulligravid women from Anhui, China, who were studied in 1996-1998. The women were followed prospectively from the time they stopped contraception until CP (gestational age ≥42 d) or 12 mo (whichever occurred first). EPL was identified by using daily urinary human chorionic gonadotropin. The women were categorized according to B-vitamin status (deficiency compared with sufficiency) and DDT concentration (high compared with low).
resultsOf 291 study women, a total of 385 conceptions (31% of which ended in EPL) and 265 CPs occurred. Compared with women with adequate B-vitamins and low DDT, incidence rates of CP were reduced in women with B-vitamin deficiency and a high DDT concentration (P < 0.05 for all). Most notably, in women with sufficient vitamin B-12, DDT was not associated with the incidence of CP; in contrast, in women with vitamin B-12 deficiency, high DDT was associated with a lower incidence of CP (HR: 0.44; 95% CI: 0.23, 0.84); and the test for interaction was significant (P < 0.05). The odds of EPL decreased by 45% (95% CI: 21%, 62%) for each interquartile distance increase in folate in women with high DDT concentrations, and the test for interaction was significant (P = 0.006).
conclusionsOur results provide suggestive evidence that vitamin B-12 and folate sufficiency may help protect against adverse reproductive effects of DDT exposure. Additional studies are needed to confirm our findings.
Indexed as
Pregnancy OutcomeAdolescentAdultChinaDDTFemaleFolic AcidFollow-Up StudiesHumansPregnancyProspective StudiesReproductionVitamin B 12Vitamin B 6Vitamin B ComplexVitamin B DeficiencyDDTFolic AcidVitamin B 12Vitamin B 6Vitamin B ComplexB vitaminclinical pregnancyDDTearly pregnancy losspreconception
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