Evidence map›Paper›PMID 25411203›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2015

Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.

José L Maravillas-Montero, Amanda M Burkhardt, Peter A Hevezi, Christina D Carnevale, Martine J Smit, Albert Zlotnik

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 161 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

José L Maravillas-MonteroDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697; Institute for Immunology, University of California, Irvine, Irvine, CA 92697; and.
Amanda M BurkhardtDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697; Institute for Immunology, University of California, Irvine, Irvine, CA 92697; and.
Peter A HeveziDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697; Institute for Immunology, University of California, Irvine, Irvine, CA 92697; and.
Christina D CarnevaleDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697; Institute for Immunology, University of California, Irvine, Irvine, CA 92697; and.
Martine J SmitInstitute for Immunology, University of California, Irvine, Irvine, CA 92697; and Division of Medicinal Chemistry, Free University Amsterdam, 1081 HV Amsterdam, the Netherlands.
Albert ZlotnikDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697; Institute for Immunology, University of California, Irvine, Irvine, CA 92697; and azlotnik@uci.edu.
University of California, Irvine · US

Funding

Characterization of CCL28,CXCL14, and CXCL17, three mucosal chemokinesR01AI093548 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZLOTNIK, ALBERT · 2012 to 2016
$1.9M
NIAID NIH HHS R01 AI093548NIAID NIH HHS R01AI093548
6 · The paper itself

Abstract

Chemokines are chemotactic cytokines that direct the traffic of leukocytes and other cells in the body. Chemokines bind to G protein-coupled receptors expressed on target cells to initiate signaling cascades and induce chemotaxis. Although the cognate receptors of most chemokines have been identified, the receptor for the mucosal chemokine CXCL17 is undefined. In this article, we show that GPR35 is the receptor of CXCL17. GPR35 is expressed in mucosal tissues, in CXCL17-responsive monocytes, and in the THP-1 monocytoid cell line. Transfection of GPR35 into Ba/F3 cells rendered them responsive to CXCL17, as measured by calcium-mobilization assays. Furthermore, GPR35 expression is downregulated in the lungs of Cxcl17(-/-) mice, which exhibit defects in macrophage recruitment to the lungs. We conclude that GPR35 is a novel chemokine receptor and suggest that it should be named CXCR8.

Indexed as

Amino Acid SequenceAnimalsCell Line, TumorChemokinesChemokines, CXCChemotaxis, LeukocyteHumansLungMacrophagesMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataMonocytesMucous MembraneProtein Structure, TertiaryChemokinesChemokines, CXCCXCL17 protein, humanCXCL17 protein, mouseGPR35 protein, humanReceptors, G-Protein-Coupled

Identifiers

PMID25411203
PMCPMC4355404
OpenAlexW2112215926

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.