ArticleThe Journal of nutrition2014
Early supplementation of phospholipids and gangliosides affects brain and cognitive development in neonatal piglets.
Article in The Journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The trial behind it
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Who cites it
50 citing papers in PubMed, 109 citations in OpenAlex.
- Effects of infant feeding type on auditory event-related potentials at 24 months of age.Pediatric research · 2025Trial
- Supplementation with milk enriched with complex lipids during pregnancy: A double-blind randomized controlled trial.PloS one · 2021Trial
- Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes.Pediatric research · 2018Trial
- Trial
- Sphingolipids in Emotional Well-Being.Journal of neurochemistry · 2026Review
- Human milk phospholipids across lactation stages and their associations with infant neurodevelopment: a prospective cohort study in China.Frontiers in nutrition · 2026Article
- Long-term cognitive benefits of human milk phospholipids in breastfed children at preschool age: results from MUAI study.European journal of nutrition · 2025Observational
- Milk-derived extracellular vesicles and gut health.NPJ science of food · 2025Review
- Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host.Microorganisms · 2025Review
- Milk metabolite composition of a semi-captive population of Asian elephants.Royal Society open science · 2024Article
- The probioticThe British journal of nutrition · 2024Article
- A combination of phospholipids and long chain polyunsaturated fatty acids supports neurodevelopmental outcomes in infants: a randomized, double-blind, controlled clinical trial.Frontiers in nutrition · 2024Article
- Dietary gangliosides rescue GM3 synthase deficiency outcomes in mice accompanied by neurogenesis in the hippocampus.Frontiers in neuroscience · 2024Article
- Lipidomic Characterization of Whey Concentrates Rich in Milk Fat Globule Membranes and Extracellular Vesicles.Biomolecules · 2023Article
- Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.Neurobiology of disease · 2023Article
- Bioactive Functions of Lipids in the Milk Fat Globule Membrane: A Comprehensive Review.Foods (Basel, Switzerland) · 2023Review
- Dynamic Interplay between Social Brain Development and Nutrient Intake in Young Children.Nutrients · 2023Article
- Fucosylated Human Milk Oligosaccharides during the First 12 Postnatal Weeks Are Associated with Better Executive Functions in Toddlers.Nutrients · 2023Article
- Milk fat globule membrane plus milk fat increase docosahexaenoic acid availability in infant formulas.European journal of nutrition · 2023Article
- Milk fat globule membrane promotes brain development in piglets by enhancing the connection of white matter fiber trace.Frontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundBecause human breast milk is a rich source of phospholipids and gangliosides and breastfed infants have improved learning compared with formula-fed infants, the importance of dietary phospholipids and gangliosides for brain development is of interest.
objectiveWe sought to determine the effects of phospholipids and gangliosides on brain and cognitive development.
methodsMale and female piglets from multiple litters were artificially reared and fed formula containing 0% (control), 0.8%, or 2.5% Lacprodan PL-20 (PL-20; Arla Foods Ingredients), a phospholipid/ganglioside supplement, from postnatal day (PD) 2 to PD28. Beginning on PD14, performance in a spatial T-maze task was assessed. At PD28, brain MRI data were acquired and piglets were killed to obtain hippocampal tissue for metabolic profiling.
resultsDiet affected maze performance, with piglets that were fed 0.8% and 2.5% PL-20 making fewer errors than control piglets (80% vs. 75% correct on average; P < 0.05) and taking less time to make a choice (3 vs. 5 s/trial; P < 0.01). Mean brain weight was 5% higher for piglets fed 0.8% and 2.5% PL-20 (P < 0.05) than control piglets, and voxel-based morphometry revealed multiple brain areas with greater volumes and more gray and white matter in piglets fed 0.8% and 2.5% PL-20 than in control piglets. Metabolic profiling of hippocampal tissue revealed that multiple phosphatidylcholine-related metabolites were altered by diet.
conclusionIn summary, dietary phospholipids and gangliosides improved spatial learning and affected brain growth and composition in neonatal piglets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.