Evidence map›Paper›PMID 25410907›Full record

ArticleMolecules and cells2014

Homing and restorative effects of bone marrow-derived mesenchymal stem cells on cisplatin injured ovaries in rats.

Jiabin Liu, Haiying Zhang, Yun Zhang, Nan Li, Yuku Wen, Fanglei Cao, Hao Ai, Xiaoou Xue

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 160 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jiabin LiuLiaoning Medical University, Jinzhou, Liaoning 121001, China ; Department of Gynecology and Obstetrics, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China ; Key laboratory of Follicular Development and Reproductive Health of Liaoning Province, Liaoning Medical University, Jinzhou, Liaoning 121001, China.
Haiying ZhangLiaoning Medical University, Jinzhou, Liaoning 121001, China.
Yun ZhangDepartment of Gynecology and Obstetrics, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China.
Nan LiDepartment of Gynecology and Obstetrics, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China.
Yuku WenDepartment of Gynecology and Obstetrics, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China.
Fanglei CaoDepartment of Gynecology and Obstetrics, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China.
Hao AiLiaoning Medical University, Jinzhou, Liaoning 121001, China ; Department of Gynecology and Obstetrics, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China ; Key laboratory of Follicular Development and Reproductive Health of Liaoning Province, Liaoning Medical University, Jinzhou, Liaoning 121001, China.
Xiaoou XueDongzhimen Hospital Affiliated to Beijing University of China Medicine, Beijing 100029, China.
Jinzhou Medical University · CNDongzhimen Hospital Affiliated to Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Premature ovarian failure (POF) is a long-term adverse effect of chemotherapy treatment. However, current available treatment regimens are not optimal. Emerging evidence suggests that bone marrow-derived mesenchymal stem cells (BMSCs) could restore the structure and function of injured tissues, but the homing and restorative effects of BMSCs on chemotherapy injured ovaries are still not clear. In this study, we found that granulosa cell (GC) apoptosis induced by cisplatin was reduced when BMSCs were migrated to granulosa cells (GCs) in vitro. Chemotherapy-induced POF was induced by intraperitoneal injection of cisplatin in rats. BMSCs labeled with enhanced green fluorescent protein (EGFP) were injected into the rats via the tail vein to investigate the homing and distribution of BMSCs in vivo. The number of BMSCs in the ovarian hilum and medulla was greater than in the cortex, but no BMSCs were found in the follicles and corpus lutea. In addition, the BMSCs treatment group's antral follicle count and estradiol levels increased after 30 days, compared with the POF group. Hence, our study demonstrates that intravenously delivered BMSCs can home to the ovaries, and restore its structure and function in POF model rats.

Indexed as

AnimalsApoptosisBone Marrow TransplantationCell MovementCells, CulturedCisplatinFemaleGranulosa CellsHumansInjections, IntraperitonealMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOrgan SpecificityPrimary Ovarian InsufficiencyRatsRats, Sprague-DawleyCisplatinbone marrow-derived mesenchymal stem cellscisplatinhomingintravenous injectionpremature ovarian failure

Identifiers

PMID25410907
PMCPMC4275703
OpenAlexW2043264689

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.