ArticlePhysical biology2014
Computational analysis of three-dimensional epithelial morphogenesis using vertex models.
Article in Physical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Modeling bulk mechanical effects in a planar cellular monolayer.Physical review. E · 2025Article
- A hybrid model of intercellular tension and cell-matrix mechanical interactions in a multicellular geometry.Biomechanics and modeling in mechanobiology · 2020Article
- Viscoelastic voyages - Biophysical perspectives on cell intercalation during Drosophila gastrulation.Seminars in cell & developmental biology · 2020Review
- Polarized cellular mechano-response system for maintaining radial size in developing epithelial tubes.Development (Cambridge, England) · 2019Article
- Mechanochemical Coupling and Junctional Forces during Collective Cell Migration.Biophysical journal · 2019Article
- Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation.PLoS computational biology · 2019Article
- Simulation of Cell Patterning Triggered by Cell Death and Differential Adhesion in Drosophila Wing.Biophysical journal · 2018Article
- Geometric constraints alter cell arrangements within curved epithelial tissues.Molecular biology of the cell · 2017Article
- Complex structures from patterned cell sheets.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Cell mechanics: a dialogue.Reports on progress in physics. Physical Society (Great Britain) · 2017Review
- Shape Transformations of Epithelial Shells.Biophysical journal · 2016Article
- Automatic stage identification of Drosophila egg chamber based on DAPI images.Scientific reports · 2016Article
- Three-dimensional vertex model for simulating multicellular morphogenesis.Biophysics and physicobiology · 2015Review
- The biophysical nature of cells: potential cell behaviours revealed by analytical and computational studies of cell surface mechanics.BMC biophysics · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The folding of epithelial sheets, accompanied by cell shape changes and rearrangements, gives rise to three-dimensional structures during development. Recently, some aspects of epithelial morphogenesis have been modeled using vertex models, in which each cell is approximated by a polygon; however, these models have been largely confined to two dimensions. Here, we describe an adaptation of these models in which the classical two-dimensional vertex model is embedded in three dimensions. This modification allows for the construction of complex three-dimensional shapes from simple sheets of cells. We describe algorithmic, computational, and biophysical aspects of our model, with the view that it may be useful for formulating and testing hypotheses regarding the mechanical forces underlying a wide range of morphogenetic processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.