ArticleClinical neuroradiology2016
Clot Burden and Collaterals in Anterior Circulation Stroke: Differences Between Single-Phase CTA and Multi-phase 4D-CTA.
Article in Clinical neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Value of thrombus imaging in predicting the outcomes of patients with large-vessel occlusive strokes after endovascular therapy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017.Stroke and vascular neurology · 2018Guideline
- Four-dimensional CTA detects non-puncture hemorrhage after percutaneous transluminal angioplasty for peripheral arterial disease.Quantitative imaging in medicine and surgery · 2026Article
- Extended Multimodal Flat Detector CT Imaging in Acute Ischemic Stroke: A Pilot Study.Journal of digital imaging · 2023Article
- Acute intracranial internal carotid artery occlusion: Extension and location of the thrombus as an influencing factor in Computed Tomography angiography findings.European journal of radiology open · 2023Article
- Role of diabetes in collateral status assessed in CT perfusion-derived dynamic CTA in anterior circulation stroke.Neuroradiology · 2022Article
- Predicting hemorrhagic transformation after thrombectomy in acute ischemic stroke: a multimodal score of the regional pial collateral.Neuroradiology · 2022Article
- Preliminary Application of a Quantitative Collateral Assessment Method in Acute Ischemic Stroke Patients With Endovascular Treatments: A Single-Center Study.Frontiers in neurology · 2021Article
- Collateral Vessels on 4D CTA as a Predictor of Hemorrhage Transformation After Endovascular Treatments in Patients With Acute Ischemic Stroke: A Single-Center Study.Frontiers in neurology · 2020Article
- Color-Mapping of 4D-CTA for the Detection of Cranial Arteriovenous Shunts.AJNR. American journal of neuroradiology · 2019Article
- Collaterals are a major determinant of the core but not the penumbra volume in acute ischemic stroke.Neuroradiology · 2019Article
- Clot Pathophysiology: Why Is It Clinically Important?Neuroimaging clinics of North America · 2018Review
- CTA-Based Truncal-Type Occlusion Is Best Matched With Postprocedural Fixed Focal Stenosis in Vertebrobasilar Occlusions.Frontiers in neurology · 2018Article
- Article
- Clinical and radiological outcome after mechanical thrombectomy in acute ischemic stroke: What matters?The neuroradiology journal · 2016Article
- Cerebral collateral circulation in experimental ischemic stroke.Experimental & translational stroke medicine · 2016Review
- An Appeal to Standardize CT- and MR-Perfusion.Clinical neuroradiology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt has been reported that the extent of intravascular thrombi and the quality of collateral filling in computed tomography (CT) angiography are predictive for the clinical outcome in patients with acute stroke. We hypothesized that multi-phase four-dimensional CTA (4D-CTA) allows better assessment of clot burden and collateral flow compared with arterial single-phase CTA (CTA).
methodsIn 49 patients (33 female; age: 77 ± 12 years) with acute anterior circulation stroke, CTA and 4D-CTA reconstructed from dynamic perfusion CT data were analyzed for absolute thrombus length (TL), clot burden score (CBS), and collateral score (CS). The length of the filling defect was also defined on thin-slice nonenhanced CT as corresponding hyperdense middle cerebral artery sign (HMCAS) when present.
resultsThere was good correlation (r = 0.62, p < 0.01) between the length of HMCAS (1.29 ± 0.62 cm) and TL in 4D-CTA (1.22 ± 0.51 cm). 4D-CTA and CTA significantly varied (p < 0.01) in TL (1.42 ± 0.73 cm (CTA) versus 1.11 ± 0.62 cm (4D-CTA)), CBS (median: 5, interquartile range: 4-7 (CTA) versus median: 6, interquartile range: 5-8 (4D-CTA); p < 0.001), and CS (median: 2, interquartile range: 1-2 (CTA) versus median: 3, interquartile range: 2-3 (4D-CTA); p < 0.001). Accordingly, CTA significantly overrated clot burden and underestimated collateral flow.
conclusions4D-CTA more closely defines clot burden and collateral supply in anterior circulation stroke than CTA, implicating an additional diagnostic benefit.
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