ReviewProgress in molecular biology and translational science2014
The intergenerational effects of early adversity.
Review in Progress in molecular biology and translational science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Antisense molecules: A promising new therapy for atopic dermatitis.Acta pharmaceutica Sinica. B · 2025Review
- Broadening the vaccine metaphor: The adequate balanced food (ABF) vaccine against tuberculosis (Acid-fast bacilli/AFB) and more.PLOS global public health · 2025Article
- Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy.Children (Basel, Switzerland) · 2024Review
- Embryonic manipulations shape life-long, heritable stress responses through complex epigenetic mechanisms: a review.Frontiers in neuroscience · 2024Review
- Multigenerational Impacts of Childhood Access to the Safety Net: Early Life Exposure to Medicaid and the Next Generation's Health.The American economic review · 2023Article
- Food and nutrient intake of school-aged children in Lebanon and their adherence to dietary guidelines and recommendations.BMC public health · 2022Article
- Leveraging the bi-directional links between health and education to promote long-term resilience and equality.Journal of the Royal Society of Medicine · 2022Article
- Social and behaviour change communication to improve child feeding practices in Ethiopia.Maternal & child nutrition · 2021Article
- Diet Quality of Malaysians across Lifespan: A Scoping Review of Evidence in a Multi-Ethnic Population.Nutrients · 2021Article
- Intergenerational effects of childhood maltreatment and malnutrition on personality maladaptivity in a Barbadian longitudinal cohort.Psychiatry research · 2020Article
- The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders.The American journal of psychiatry · 2020Review
- Childhood Undernutrition and Its Predictors in a Rural Health and Demographic Surveillance System Site in South Africa.International journal of environmental research and public health · 2019Article
- Seeking Biomarkers of Early Childhood Malnutrition's Long-term Effects.MEDICC review · 2018Article
- The influence of maternal psychosocial circumstances and physical environment on the risk of severe wasting in rural Gambian infants: a mixed methods approach.BMC public health · 2018Article
- Different Behavioral Experiences Produce Distinctive Parallel Changes in, and Correlate With, Frontal Cortex and Hippocampal Global Post-translational Histone Levels.Frontiers in integrative neuroscience · 2018Article
- Association of the World War II Finnish Evacuation of Children With Psychiatric Hospitalization in the Next Generation.JAMA psychiatry · 2018Article
- Executive Summary: Research Gaps at the Intersection of Pediatric Neurodevelopment, Nutrition, and Inflammation in Low-Resource Settings.Pediatrics · 2017Article
- Neurodevelopment: The Impact of Nutrition and Inflammation During Adolescence in Low-Resource Settings.Pediatrics · 2017Review
- Slow Physical Growth, Delayed Reflex Ontogeny, and Permanent Behavioral as Well as Cognitive Impairments in Rats Following Intra-generational Protein Malnutrition.Frontiers in neuroscience · 2015Article
- An Epigenetics-Based, Lifestyle Medicine-Driven Approach to Stress Management for Primary Patient Care: Implications for Medical Education.American journal of lifestyle medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Early insults during critical periods of brain development, both prenatal and postnatal, can result in epigenetic changes that may impact health and behavioral outcomes over the life span and into future generations. There is ample evidence that these early stages of brain development are sensitive to various environmental insults, including malnutrition, childhood trauma, and drug exposures. The notion that such changes, both physiological and behavioral, can also carry over into subsequent generations has long been recognized, especially in the context of experimental studies. However, epigenetic mechanisms capable of explaining such phenomena were not available until relatively recently, with most of this research published only within the last decade.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.