Evidence map›Paper›PMID 25410535›Full record

ReviewCritical reviews in biochemistry and molecular biology

Rhythmic control of activity and sleep by class B1 GPCRs.

Michael Kunst, Matthew C F Tso, D Dipon Ghosh, Erik D Herzog, Michael N Nitabach

Open access · greenAbstract readReview
In one paragraph

Review in Critical reviews in biochemistry and molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. International journal of molecular sciences · 2019
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael KunstDepartment of Cellular and Molecular Physiology, Yale University School of Medicine , New Haven, CT , USA and.
Matthew C F Tso
D Dipon Ghosh
Erik D Herzog
Michael N Nitabach
Yale University · USWashington University in St. Louis · US

Funding

Synaptic Microcircuits Underlying Associative LearningR01NS091070 · NINDS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2014 to 2024
$4.0M
Transgenic Tethered Spider ToxinsR01NS056443 · NINDS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2006 to 2014
$3.4M
Peptide Modulation of Physiology and BehaviorR01GM098931 · NIGMS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2011 to 2019
$3.0M
Calcium Signaling in Circadian Clock NeuronsR01NS055035 · NINDS · YALE UNIVERSITY · PI NITABACH, MICHAEL · 2008 to 2012
$1.8M
NIGMS NIH HHS R01 GM098931NINDS NIH HHS R01 NS055035NINDS NIH HHS R01 NS056443NINDS NIH HHS R01 NS091070
6 · The paper itself

Abstract

Members of the class B1 family of G-protein coupled receptors (GPCRs) whose ligands are neuropeptides have been implicated in regulation of circadian rhythms and sleep in diverse metazoan clades. This review discusses the cellular and molecular mechanisms by which class B1 GPCRs, especially the mammalian VPAC2 receptor and its functional homologue PDFR in Drosophila and C. elegans, regulate arousal and daily rhythms of sleep and wake. There are remarkable parallels in the cellular and molecular roles played by class B1 intercellular signaling pathways in coordinating arousal and circadian timekeeping across multiple cells and tissues in these very different genetic model organisms.

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCircadian RhythmDrosophilaDrosophila ProteinsHumansPhylogenyReceptors, G-Protein-CoupledSleepCaenorhabditis elegans ProteinsDrosophila ProteinsPDFR protein, DrosophilaReceptors, G-Protein-CoupledCircadianDrosophilaG-protein coupled receptorneuropeptidessleepsuprachiasmatic nucleus

Identifiers

PMID25410535
PMCPMC4648372
OpenAlexW2010553164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.