ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
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- Familial Melanoma and Susceptibility Genes: A Review of the Most Common Clinical and Dermoscopic Phenotypic Aspect, Associated Malignancies and Practical Tips for Management.Journal of clinical medicine · 2021Review
- The Metabolite Profile in Culture Supernatant ofPlants (Basel, Switzerland) · 2021Article
- MC1R variants in relation to naevi in melanoma cases and controls: a pooled analysis from the M-SKIP project.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Article
- Melanogenic Difference Consideration in Ethnic Skin Type: A Balance Approach Between Skin Brightening Applications and Beneficial Sun Exposure.Clinical, cosmetic and investigational dermatology · 2020Review
- MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort.The Lancet. Child & adolescent health · 2019Article
- Cutaneous nevi and risk of melanoma death in women and men: A prospective study.Journal of the American Academy of Dermatology · 2019Article
- Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci.Nature genetics · 2017Article
- Acquired melanocytic naevus phenotypes andPeerJ · 2017Article
- EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling.Cell reports · 2016Article
- Sunburn, sun exposure, and sun sensitivity in the Study of Nevi in Children.Annals of epidemiology · 2015Article
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13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMelanocytic nevi (moles) and freckles are well known biomarkers of melanoma risk, and they are influenced by similar UV light exposures and genetic susceptibilities to those that increase melanoma risk. Nevertheless, the selective interactions between UV exposures and nevus and freckling genes remain largely undescribed.
methodsWe conducted a longitudinal study from ages 6 through 10 years in 477 Colorado children who had annual information collected for sun exposure, sun protection behaviors, and full body skin exams. MC1R and HERC2/OCA2 rs12913832 were genotyped and linear mixed models were used to identify main and interaction effects.
resultsAll measures of sun exposure (chronic, sunburns, and waterside vacations) contributed to total nevus counts, and cumulative chronic exposure acted as the major driver of nevus development. Waterside vacations strongly increased total nevus counts in children with rs12913832 blue eye color alleles and facial freckling scores in those with MC1R red hair color variants. Sunburns increased the numbers of larger nevi (≥2 mm) in subjects with certain MC1R and rs12913832 genotypes.
conclusionsComplex interactions between different UV exposure profiles and genotype combinations determine nevus numbers and size, and the degree of facial freckling. IMPACT: Our findings emphasize the importance of implementing sun-protective behavior in childhood regardless of genetic make-up, although children with particular genetic variants may benefit from specifically targeted preventive measures to counteract their inherent risk of melanoma. Moreover, we demonstrate, for the first time, that longitudinal studies are a highly powered tool to uncover new gene-environment interactions that increase cancer risk.
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