ArticleBMC pregnancy and childbirth2014
Serum calcium and magnesium levels in women presenting with pre-eclampsia and pregnancy-induced hypertension: a case-control study in the Cape Coast metropolis, Ghana.
Article in BMC pregnancy and childbirth, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- The association of malaria infection and gestational hypertension in Africa: Systematic review and meta-analysis.Journal of global health · 2020Pooled it
- Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis.Nutrients · 2017Pooled it
- Overweight and obesity epidemic in Ghana-a systematic review and meta-analysis.BMC public health · 2016Pooled it
- Effects of prenatal micronutrients supplementation timing on pregnancy-induced hypertension: Secondary analysis of a double-blind randomized controlled trial.Maternal & child nutrition · 2021Trial
- Factors associated with pharmacologic serum concentration of magnesium and corresponding obstetric outcomes among women with severe preeclampsia at Iringa regional referral hospital.BMC pregnancy and childbirth · 2026Article
- Beyond magnesium sulphate - Rethinking magnesium's impact on maternal and foetal health in low to middle-income countries: A scoping review.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026Article
- Evaluation of Serum Lactate Dehydrogenase and Electrolyte Levels Among Preeclamptic Women at the University of Gondar Comprehensive Specialized Hospital, Northwest, Ethiopia: A Comparative Cross-Sectional Study.Journal of pregnancy · 2026Article
- The association between serum magnesium levels and hypertensive disorders of pregnancy.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025Article
- Strong association between hypocalcemia and preeclampsia-eclampsia among pregnant women attending at a tertiary referral hospital in Northwestern Tanzania.Scientific reports · 2025Article
- Association of Serum Magnesium and Calcium Levels in Patients with and without Diastolic Notch in Uterine Artery Doppler Ultrasonography Imaging in the Second Trimester.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Circulating Potassium/Magnesium Ratio, Thyroid Stimulating Hormone, Fasting Plasma Glucose, Oxidized LDL/Albumin Ratio, and Urinary Iodine Concentration Are Possible Entities for Screening for Preeclampsia in Low-Resource Settings.Medicina (Kaunas, Lithuania) · 2025Article
- The Association Between Diabetes Mellitus and Perianal Abscess: A Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Association of hypertension in pregnancy with serum electrolyte disorders in late pregnancy among Cameroonian women.Scientific reports · 2023Article
- Longitudinal Assessment of Calcium and Magnesium Levels in Women with Preeclampsia.Biological trace element research · 2023Observational
- Effect of magnesium sulfate treatment on mediators of endothelial dysfunction and electrolytes in mild and severe preeclampsia: A case-control study.Health science reports · 2023Article
- Analysis of serum calcium, sodium, potassium, zinc, and iron in patients with pre-eclampsia in Bangladesh: A case-control study.Health science reports · 2023Article
- Calcium, Potassium, Sodium, and Magnesium Concentrations in the Placenta, Umbilical Cord, and Fetal Membrane from Women with Multiple Pregnancies.Life (Basel, Switzerland) · 2023Article
- Serum Calcium and Magnesium Levels in Women Presenting with Pre-eclampsia: A Systematic Review and Meta-analysis Based on Observational Studies.Galen medical journal · 2023Review
- Associations of serum concentrations of metal nutrients with postpartum anemia among pregnant Chinese women: A large retrospective cohort study.Frontiers in nutrition · 2023Article
- Maternal nutritional risk factors for pre-eclampsia incidence: findings from a narrative scoping review.Reproductive health · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertensive disorders of pregnancy are important causes of morbidity and mortality. The levels of calcium (Ca2+) and magnesium (Mg2+) in pregnancy may implicate their possible role in pregnancy-induced hypertension. This study assessed serum Ca2+ and Mg2+ levels in women with PIH (pregnancy-induced hypertension) and PE (pre-eclampsia), compared to that in normal pregnancy.
methodsThis case-control study was conducted on 380 pregnant women (≥20 weeks gestation) receiving antenatal care at three hospitals in the Cape Coast metropolis, Ghana. This comprised 120 women with PIH, 100 women with PE and 160 healthy, age-matched pregnant women (controls). Demographic, anthropometric, clinical and obstetric data were gathered using an interview-based questionnaire. Venous blood samples were drawn for the estimation of calcium and magnesium.
resultsSystolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly raised in women with PIH (p < 0.0001) and PE (p < 0.0001). Women with hypertensive disorders (PE and PIH) had significantly lower serum calcium and magnesium levels than those in the control group (p < 0.0001 each). Of those with PIH, SBP correlated positively with BMI (r = 0.575, p < 0.01) and Ca2+ correlated positively with Mg2+ (r = 0.494, p < 0.01). This was similar amongst the PE group for SBP and BMI as well as for Ca2+and Mg2+ but was not significant. Multivariate analysis showed that women aged ≥40 years were at a significant risk of developing PIH (OR = 2.14, p = 0.000).
conclusionIn this study population, serum calcium and magnesium levels are lower in PIH and PE than in normal pregnancy. Mineral supplementation during the antenatal period may influence significantly, the occurrence of hypertensive disorders in pregnancy.
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