ArticleJournal of nephrology2015
Elevated uric acid level as a significant predictor of chronic kidney disease: a cohort study with repeated measurements.
Article in Journal of nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on serum uric acid levels in patients with chronic kidney disease: a systematic review and network meta-analysis.BMJ open diabetes research & care · 2024Pooled it
- A systematic review and meta-analysis of the association between uric acid levels and chronic kidney disease.Scientific reports · 2022Pooled it
- Simiao Decoction alleviates hyperuricemia-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins.NPJ biofilms and microbiomes · 2026Article
- Identification of age-specific risk factors for hyperuricemia: a machine learning-driven stratified analysis in health examination cohorts.BMC medical informatics and decision making · 2025Article
- Association of serum uric acid with all-cause and cardiovascular mortality in cardiovascular disease patients.Scientific reports · 2024Article
- Gut microbiota dysbiosis in hyperuricaemia promotes renal injury through the activation of NLRP3 inflammasome.Microbiome · 2024Article
- Analyzing Longitudinal Health Screening Data with Feature Ensemble and Machine Learning Techniques: Investigating Diagnostic Risk Factors of Metabolic Syndrome for Chronic Kidney Disease Stages 3a to 3b.Diagnostics (Basel, Switzerland) · 2024Article
- Exploring multifaceted factors in chronic kidney disease risk: A comprehensive analysis of biochemistry, lifestyle, and inflammation in elderly Chinese individuals.World journal of clinical cases · 2024Article
- The Bidirectional Relationship between Chronic Kidney Disease and Hyperuricemia: Evidence from a Population-Based Prospective Cohort Study.International journal of environmental research and public health · 2023Article
- Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbalPharmaceutical biology · 2022Article
- Prediction models and nomograms of 3-year risk of chronic kidney disease in China: a study from the Shanghai Suburban Adult Cohort and Biobank (2016-2020).Annals of translational medicine · 2021Article
- Serum uric acid and risk of incident chronic kidney disease: a national cohort study and updated meta-analysis.Nutrition & metabolism · 2021Article
- Management of Hyperuricemia in Patients with Chronic Kidney Disease: a Focus on Renal Protection.Current hypertension reports · 2020Review
- Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia.Acta pharmaceutica Sinica. B · 2020Article
- Observational
- Uric acid stones increase the risk of chronic kidney disease.Urolithiasis · 2018Article
- Uric acid upregulates the adiponectin‑adiponectin receptor 1 pathway in renal proximal tubule epithelial cells.Molecular medicine reports · 2018Article
- Physiology of Hyperuricemia and Urate-Lowering Treatments.Frontiers in medicine · 2018Review
- Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review.Journal of advanced research · 2017Review
- Relationship between diurnal blood pressure and renal histopathological changes in white coat hypertension.Journal of nephrology · 2017Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCohort studies evaluating increased serum uric acid (SUA) level as a chronic kidney disease (CKD) risk factor have yielded variable results. We aimed to assess the association between the pattern of longitudinal changes in SUA and incident CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2)].
methodsA population-based cohort study was conducted on 3,605 participants who were followed prospectively for a mean of 5.18 years. The longitudinal changes in SUA were categorized into three subgroups: persistently low, fluctuated (reduced or elevated), and persistently high. The primary outcome of interest was the development of CKD at a follow-up examination. Cox proportional hazards analysis was used to test the hypothesis.
resultsAfter adjustment for potential confounders, participants with fluctuated SUA with progressively elevated level and persistently high SUA level had significantly higher risk of developing CKD compared to subjects with persistently low SUA level: adjusted hazard ratio (95% confidence interval) was 2.05 (1.24-3.38) vs. 1.90 (1.34-2.71). This longitudinal relationship was independent of sex, age, body mass index, and hypertension status.
conclusionsLongitudinally elevated SUA independently predicts the risk of new-onset CKD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.