ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2015
Risk factors associated with Clostridium difficile infection in adult oncology patients.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Clinical outcomes of antimicrobial resistance in cancer patients: a systematic review of multivariable models.BMC infectious diseases · 2023Pooled it
- Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysis.World journal of gastroenterology · 2017Pooled it
- Impact ofJournal of Korean medical science · 2025Article
- Clinical Impact of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor AssociatedOncoTargets and therapy · 2022Article
- Analysis of Perioperative Risk Factors for Clostridium difficile Infection After a Colectomy.Cureus · 2021Article
- To study the contributing factors and outcomes of Clostridioides difficile infection in patients with solid tumors.Heliyon · 2021Article
- Prospective Multicenter Study of Chemotherapy-InducedFrontiers in oncology · 2021Article
- High Prevalence of Genetically RelatedFrontiers in microbiology · 2020Article
- Intensity of Therapy for Malignancy and Risk for Recurrent and Complicated Clostridium difficile Infection in Children.Journal of pediatric hematology/oncology · 2019Article
- Incidence, course, and outcome of Clostridium difficile infection in children with hematological malignancies or undergoing hematopoietic stem cell transplantation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Risks factors and outcomes of Clostridium difficile infection in patients with cancer: a matched case-control study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Impact of malignancy on Clostridium difficile infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Clostridium difficile Infection in Special High-Risk Populations.Infectious diseases and therapy · 2016Review
- Risk factors for Clostridium difficile infection in hemato-oncological patients: A case control study in 144 patients.Scientific reports · 2016Article
- Article
- WSES guidelines for management of Clostridium difficile infection in surgical patients.World journal of emergency surgery : WJES · 2015Review
- Article
- 2019 update of the WSES guidelines for management ofWorld journal of emergency surgery : WJESReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeClostridium difficile infection (CDI) prevention is particularly important for cancer patients, because diarrhea often results in dose reductions or delays of chemotherapy or radiotherapy. We conducted this study to better ascertain the incidence, susceptibility, and risk factors for CDI in cancer patients receiving chemotherapy at our hospital.
methodsWe performed a retrospective study among adult cancer patients admitted at "12 de Octubre" University Hospital between January 2009 through April 2013 who were diagnosed with diarrhea. Inpatient data were available on hospital medical records. We screened by immunochromatography system detecting glutamate dehydrogenase antigen, and C. difficile toxins A and B. Later, a polymerase chain reaction for detecting toxin B gene was performed.
resultsA total of 225 patients were included in the study, and 39 of them (17.3 %) were diagnosed with CDI. Type of tumor significantly differed between CDI patients, thus relative risk in each type of cancer was calculated after adjusting for age, antibiotic exposure, corticosteroid, and proton-pump inhibitor use. Patients with gastrointestinal tumors were less prone to CDI. Conversely, breast cancer patients have a greater predisposition to CDI. Antibiotic treatment was found to be associated with an increasing risk for CDI in breast cancer patients. Curiously, exposure to proton-pump inhibitors appeared protective in our cohort, except for lung cancer patients. However, we have not been able to find an association between a particular type of chemotherapy and CDI.
conclusionsWe underscore the urgent need for early recognition and diagnosis of CDI in cancer patients. Our findings indicate a probable association between antibiotic use and CDI incidence, at least in certain cancer, such as breast cancer.
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