Trial reportArquivos brasileiros de cardiologia2015
Impact of light salt substitution for regular salt on blood pressure of hypertensive patients.
Trial report in Arquivos brasileiros de cardiologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 13 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Efficacy of a Salt Substitute on the Incidence of Hypertension: A Systematic Review with Meta-Analysis.Arquivos brasileiros de cardiologia · 2026Pooled it
- Pooled it
- Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis.BMC medicine · 2026Pooled it
- Knowledge, attitudes, and behaviours related to reduced-sodium salt: a systematic review.Journal of human hypertension · 2026Pooled it
- Effectiveness of salt substitute on cardiovascular outcomes: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2022Pooled it
- Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women.The Cochrane database of systematic reviews · 2022Pooled it
- Pooled it
- Pooled it
- Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride.The Cochrane database of systematic reviews · 2020Pooled it
- Nonpharmacologic Interventions for Reducing Blood Pressure in Adults With Prehypertension to Established Hypertension.Journal of the American Heart Association · 2020Pooled it
- The hypotensive effect of salt substitutes in stage 2 hypertension: a systematic review and meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride.The Cochrane database of systematic reviews · 2017Pooled it
- The Science of Salt: A Regularly Updated Systematic Review of Salt and Health Outcomes (August to November 2015).Journal of clinical hypertension (Greenwich, Conn.) · 2016Pooled it
- Effects of added salt reduction on central and peripheral blood pressure.Arquivos brasileiros de cardiologiaTrial
- Effects of sodium reduction interventions on home and morning home blood pressure: a systematic review and meta-analysis of randomized controlled trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Blood Pressure Reduction Effects of Salt Substitutes in Different Application Settings A Meta-Analysis of Randomized Controlled Trials.JACC. Asia · 2026Article
- The Relationship between Low-Sodium Salt Intake and Both Blood Pressure Level and Hypertension in Chinese Residents.Nutrients · 2024Article
- A multicomponent family intervention, combined with salt reduction for children with obesity: a factorial randomized study protocol.BMC public health · 2023Article
- Article
- Strengthening Knowledge to Practice on Effective Salt Reduction Interventions in Low- and Middle-Income Countries.Current nutrition reports · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies have shown sodium restriction to have a beneficial effect on blood pressure (BP) of hypertensive patients.
objectiveTo evaluate the impact of light salt substitution for regular salt on BP of hypertensive patients.
methodsUncontrolled hypertensive patients of both sexes, 20 to 65 years-old, on stable doses of antihypertensive drugs were randomized into Intervention Group (IG - receiving light salt) and Control Group (CG - receiving regular salt). Systolic BP (SBP) and diastolic BP (DBP) were analyzed by using casual BP measurements and Home Blood Pressure Monitoring (HBPM), and sodium and potassium excretion was assessed on 24-hour urine samples. The patients received 3 g of salt for daily consumption for 4 weeks.
resultsThe study evaluated 35 patients (65.7% women), 19 allocated to the IG and 16 to the CG. The mean age was 55.5 ± 7.4 years. Most participants had completed the Brazilian middle school (up to the 8th grade; n = 28; 80.0%), had a family income of up to US$ 600 (n = 17; 48.6%) and practiced regular physical activity (n = 19; 54.3%). Two patients (5.7%) were smokers and 40.0% consumed alcohol regularly (n = 14). The IG showed a significant reduction in both SBP and DBP on the casual measurements and HBPM (p < 0.05) and in sodium excretion (p = 0.016). The CG showed a significant reduction only in casual SBP (p = 0.032).
conclusionsThe light salt substitution for regular salt significantly reduced BP of hypertensive patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.