Evidence map›Paper›PMID 25409697›Full record

ReviewNature reviews. Neuroscience2014

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies.

Mauro Maccarrone, Manuel Guzmán, Ken Mackie, Patrick Doherty, Tibor Harkany

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 1 pooled it
24.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 1 synthesis or guideline pooled it, 294 citations in OpenAlex.

  1. Pooled it
  2. The endocannabinoid system and the ageing brain.Nature reviews. Neuroscience · 2026
    Review
  3. Review
  4. Ageing, Neurodegeneration and the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
    Review
  5. Article
  6. Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Cannabinoids: Role in Neurological Diseases and Psychiatric Disorders.International journal of molecular sciences · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 5 countries.

Mauro Maccarrone1] School of Medicine and Center of Integrated Research, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, I-00128 Rome, Italy. [2] European Center for Brain Research/Santa Lucia Foundation, Via del Fosso di Fiorano 65, I-00143 Rome, Italy.
Manuel GuzmánDepartment of Biochemistry and Molecular Biology I and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Complutense University, E-28040 Madrid, Spain.
Ken MackieDepartment of Psychological and Brain Sciences, Indiana University, 702 N Walnut Grove Avenue, Bloomington, Indiana 47405-2204, USA.
Patrick DohertyWolfson Centre for Age-Related Diseases, King's College, London SE1 1UL, United Kingdom.
Tibor Harkany1] Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1:A1, Karolinska Institutet, SE-17177 Stockholm, Sweden. [2] Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria.
Centro de Investigación Biomédica en Red · ESEugene O'Neill Theater Center · USKarolinska Institutet · SEKing's College London · GBUniversità Campus Bio-Medico · IT

Funding

Neurodevelopmental Effects of Cannabis and its Epigenetic RegulationR01DA030359 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HURD, YASMIN L. · 2011 to 2020
$5.5M
Neuronal cannabinoidsR01DA011322 · NIDA · UNIVERSITY OF WASHINGTON · PI MACKIE, KENNETH · 1998 to 2014
$3.4M
The neuronal basis of cannabis-induced developmental deficits in the CNSR01DA023214 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HURD, YASMIN L. · 2008 to 2012
$1.6M
Cannabinoid Modulation of Cell FunctionK05DA021696 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI MACKIE, KENNETH · 2007 to 2017
$1.3M
NIDA NIH HHS DA011322NIDA NIH HHS DA021696NIDA NIH HHS DA023214NIDA NIH HHS K05 DA021696NIDA NIH HHS R01 DA011322NIDA NIH HHS R01 DA023214NIDA NIH HHS R01 DA030359Wellcome Trust
6 · The paper itself

Abstract

Among the many signalling lipids, endocannabinoids are increasingly recognized for their important roles in neuronal and glial development. Recent experimental evidence suggests that, during neuronal differentiation, endocannabinoid signalling undergoes a fundamental switch from the prenatal determination of cell fate to the homeostatic regulation of synaptic neurotransmission and bioenergetics in the mature nervous system. These studies also offer novel insights into neuropsychiatric disease mechanisms and contribute to the public debate about the benefits and the risks of cannabis use during pregnancy and in adolescence.

Indexed as

AnimalsCannabisCell DifferentiationEndocannabinoidsFemaleHumansNeurogenesisNeuronsPregnancyEndocannabinoids

Identifiers

PMID25409697
PMCPMC4765324
OpenAlexW2094350005

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.