ArticlePloS one2014
Identification of highly conserved putative developmental enhancers bound by SOX3 in neural progenitors using ChIP-Seq.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Srr2-dependent SOX2 levels govern the chromatin and transcriptional landscape of adult neural stem cell fate decisions in mouse.Genome biology · 2026Article
- The Charcot-Marie-Tooth Neuropathy (CMTX3) Complex Structural Variation Causes Differential SOX3 Spatiotemporal Expression.Human mutation · 2026Article
- Integrative Single-Cell Analysis Decodes Gene Expression and Chromatin Accessibility in the Developing Human Fetal Brain.Molecular neurobiology · 2025Article
- A complex structural variant nearHGG advances · 2023Article
- Characterization of the transcription factor Sox3 regulating the gonadal development of pearlscale angelfish (Centropyge vrolikii).Fish physiology and biochemistry · 2022Article
- Variational autoencoding of gene landscapes during mouse CNS development uncovers layered roles of Polycomb Repressor Complex 2.Nucleic acids research · 2022Article
- δ-Protocadherins regulate neural progenitor cell division by antagonizing Ryk and Wnt/β-catenin signaling.iScience · 2021Article
- Article
- SOX3 promotes generation of committed spermatogonia in postnatal mouse testes.Scientific reports · 2020Article
- Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Article
- The Cadherin Superfamily in Neural Circuit Assembly.Cold Spring Harbor perspectives in biology · 2018Review
- Widespread enhancer activation via ERα mediates estrogen response in vivo during uterine development.Nucleic acids research · 2018Article
- sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish.Developmental biology · 2018Article
- Deconvolution of Transcriptional Networks in Post-Traumatic Stress Disorder Uncovers Master Regulators Driving Innate Immune System Function.Scientific reports · 2017Article
- δ-Protocadherins: Organizers of neural circuit assembly.Seminars in cell & developmental biology · 2017Review
- Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells.PloS one · 2017Article
- Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1.Scientific reports · 2016Article
- Molecular Cloning, Promoter Analysis and Expression Profiles of the sox3 Gene in Japanese Flounder, Paralichthys olivaceus.International journal of molecular sciences · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor SOX3 is expressed within most neural progenitor (NP) cells of the vertebrate central nervous system (CNS) and is essential for normal brain development in mice and humans. However, despite the widespread expression of Sox3, CNS defects in null mice are relatively mild due to functional redundancy with the other SOXB1 sub-group members Sox1 and Sox2. To further understand the molecular function of SOX3, we investigated the genome-wide binding profile of endogenous SOX3 in NP cells using ChIP-seq. SOX3 binding was identified at over 8,000 sites, most of which were intronic or intergeneic and were significantly associated with neurodevelopmental genes. The majority of binding sites were moderately or highly conserved (phastCons scores >0.1 and 0.5, respectively) and included the previously characterised, SOXB1-binding Nestin NP cell enhancer. Comparison of SOX3 and published ChIP-Seq data for the co-activator P300 in embryonic brain identified hundreds of highly conserved putative enhancer elements. In addition, we identified a subset of highly conserved putative enhancers for CNS development genes common to SOXB1 members in NP cells, all of which contained the SOX consensus motif (ACAAWR). Together these data implicate SOX3 in the direct regulation of hundreds of NP genes and provide molecular insight into the overlapping roles of SOXB1 proteins in CNS development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.