ArticlePloS one2014
Chest computed tomography findings in HIV-infected individuals in the era of antiretroviral therapy.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Prevalence of emphysema in people living with human immunodeficiency virus in the current combined antiretroviral therapy era: A systematic review.Frontiers in medicine · 2022Pooled it
- Cystic Bronchiectasis due to AIDS: Case and References.Balkan medical journal · 2026Article
- CT imaging of HIV-associated pulmonary disorders in COVID-19 pandemic.Clinical imaging · 2023Review
- Chronic obstructive pulmonary disease in HIV.Expert review of respiratory medicine · 2021Review
- Prevalence and predictors of airflow obstruction in an HIV tertiary care clinic in Montreal, Canada: a cross-sectional study.HIV medicine · 2019Article
- Human Immunodeficiency Virus-Associated Chronic Lung Disease in Children and Adolescents in Zimbabwe: Chest Radiographic and High-Resolution Computed Tomographic Findings.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Long-term pulmonary complications in perinatally HIV-infected youth.The Journal of allergy and clinical immunology · 2017Article
- HIV Infection Is Independently Associated with Increased CT Scan Lung Density.Academic radiology · 2017Article
- Lung Malignancies in HIV Infection.Seminars in respiratory and critical care medicine · 2016Review
- Obstructive Lung Diseases in HIV: A Clinical Review and Identification of Key Future Research Needs.Seminars in respiratory and critical care medicine · 2016Review
- Maintaining lung health with longstanding HIV.Current opinion in infectious diseases · 2016Review
- Emphysema Distribution and Diffusion Capacity Predict Emphysema Progression in Human Immunodeficiency Virus Infection.PloS one · 2016Article
- The Profile of the Patients with Double Infection HIV and TB in South West of Romania.Current health sciences journalArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChest radiographic abnormalities were common in HIV-infected individuals in the pre-combination antiretroviral therapy era, but findings may differ now due to a changing spectrum of pulmonary complications.
methodsCross-sectional study of radiographic abnormalities in an HIV-infected outpatient population during the antiretroviral therapy era. Demographics, chest computed tomography, and pulmonary function tests were obtained in HIV-infected volunteers without acute respiratory illness from the University of Pittsburgh HIV/AIDS clinic. Overall prevalence of radiographic abnormalities and potential risk factors for having any abnormality, nodules, or emphysema were evaluated using univariate and multivariable analyses.
resultsA majority of the 121 participants (55.4%) had a radiographic abnormality with the most common being emphysema (26.4%), nodules (17.4%), and bronchiectasis (10.7%). In multivariate models, age (odds ratio [OR] per year = 1.07, 95% confidence interval [CI] 1.04-1.14, p<0.001), pneumonia history (OR = 3.60, 95% CI = 1.27-10.20, p = 0.016), and having ever smoked (OR = 3.66, p = 0.013, 95% CI = 1.31-10.12) were significant predictors of having any radiographic abnormality. Use of antiretroviral therapy, CD4 cell count, and HIV viral load were not associated with presence of abnormalities. Individuals with radiographic emphysema were more likely to have airway obstruction on pulmonary function tests. Only 85.8% participants with nodules had follow-up imaging resulting in 52.4% having stable nodules, 23.8% resolution of their nodules, 4.8% development of a new nodule, and 4.8% primary lung cancer.
conclusionsRadiographic abnormalities remain common in HIV-infected individuals with emphysema, nodules, and bronchiectasis being the most common. Age, smoking, and pneumonia were associated with radiographic abnormalities, but HIV-associated factors did not seem to predict risk.
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