Evidence map›Paper›PMID 25409261›Full record

ArticleThe New England journal of medicine2014

Somatic mutations and immunotherapy outcome with CTLA-4 blockade in melanoma.

Vassiliki A Boussiotis

Open access · greenAbstract readEditorialComment
In one paragraph

Article in The New England journal of medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  20. Thoracic Complications of Precision Cancer Therapies: A Practical Guide for Radiologists in the New Era of Cancer Care.Radiographics : a review publication of the Radiological Society of North America, Inc
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Vassiliki A BoussiotisFrom the Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston.
Beth Israel Deaconess Medical Center · US

Funding

Effects of PGE2 on Reconstitution of Hematopoiesis and Immunity after UCBTR01CA183605 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BOUSSIOTIS, VASSILIKI A, CUTLER, COREY S · 2013 to 2017
$3.8M
The role of RIAM in T cell immunity and toleranceR56AI098129 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BOUSSIOTIS, VASSILIKI A · 2013 to 2013
$409k
NCI NIH HHS R01 CA183605NIAID NIH HHS R56 AI098129
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsCTLA-4 AntigenFemaleHumansIpilimumabMaleMelanomaSkin NeoplasmsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsCTLA-4 AntigenIpilimumabtremelimumab

Identifiers

PMID25409261
PMCPMC4456677
OpenAlexW2061164905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.