Evidence map›Paper›PMID 25409108›Full record

ArticleSleep2015

Sleep apnea and the risk of chronic kidney disease: a nationwide population-based cohort study.

Yi-Che Lee, Shih-Yuan Hung, Hao-Kuang Wang, Chi-Wei Lin, Hsi-Hao Wang, Shih-Wei Chen, Min-Yu Chang, Li-Chun Ho, Yi-Ting Chen, Hung-Hsiang Liou and 5 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
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  7. Sleep-Related Disorders in Patients with CKD and Kidney Transplant Recipients.Clinical journal of the American Society of Nephrology : CJASN · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Yi-Che LeeDivision of Nephrology, Department of Internal Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Shih-Yuan HungDivision of Nephrology, Department of Internal Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Hao-Kuang WangDepartment of Neurosurgery, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Chi-Wei LinDepartment of Medical Education, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Hsi-Hao WangDivision of Nephrology, Department of Internal Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Shih-Wei ChenDepartment of Family Medicine, Hsinchu Cathay General Hospital, Hsinchu, Taiwan.
Min-Yu ChangDivision of Nephrology, Department of Internal Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Li-Chun HoDivision of Nephrology, Department of Internal Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Yi-Ting ChenDivision of Nephrology, Department of Internal Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Hung-Hsiang LiouDivision of Nephrology, Department of Medicine, Hsin-Jen Hospital, New Taipei City, Taiwan.
Tsuen-Chiuan TsaiDepartment of Pediatrics, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Shih-Hann TsengHong-En Clinic, Kaohsiung, Taiwan.
Wei-Ming WangBiostatistics Consulting Center, National Cheng Kung University Hospital, Tainan, Taiwan.
Sheng-Hsiang LinInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yuan-Yow ChiouInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
I-Shou University · TWNational Cheng Kung University · TWCathay General Hospital · TWJen-Ai Hospital · TWNational Cheng Kung University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesSleep apnea (SA) is characterized by apnea during sleep and is associated with cardiovascular diseases and an increase in all-cause mortality. Chronic kidney disease (CKD) is a global health problem that has placed a substantial burden on healthcare resources. However, the relationship between SA and the incidence of CKD is not clear. This study aimed to determine whether SA is an independent risk factor for the development of CKD.

designRetrospective cohort study.

settingNational Health Insurance Research Database (NHIRD) of Taiwan. PATIENTS OR

participantsA total of 4,674 adult patients (age ≥ 30 y) in whom SA was newly diagnosed from 2000 to 2010 were included, together with 23,370 non-SA patients as the comparison group. The two groups were frequency-matched for sex, age, and year of receiving medical service. Each individual was followed until 2011.

interventionsN/A. MEASUREMENTS AND

resultsThese two groups were monitored and observed for the occurrence of CKD. Patients with SA experienced a 1.94-fold increase (95% confidence interval [CI], 1.52-2.46; P < 0.001) in the incidence of CKD, which was independent of sex, age, and comorbid medical conditions. Additionally, they showed a 2.2-fold increase (95% CI, 1.31-3.69; P < 0.01) in the incidence of end-stage renal disease (ESRD).

conclusionsPatients with sleep apnea are at increased risk for chronic kidney disease and end-stage renal disease compared with the general population. As such, screening renal function and treatment of chronic kidney disease is an important issue in patients with sleep apnea.

Indexed as

AdultFemaleHumansIncidenceKidney Failure, ChronicLongitudinal StudiesMaleMiddle AgedRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsSleep Apnea SyndromesTaiwanchronic kidney diseasecohort studyend-stage renal diseaseNational Health Insurancesleep apnea

Identifiers

PMID25409108
PMCPMC4288602
OpenAlexW2013788047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.