ArticleAmerican journal of respiratory and critical care medicine2015
New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense.
Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Serum Epithelial Biomarkers and Oxidative Stress Indicators in Acute Bronchiolitis: Association with Disease Severity and Recurrent Wheezing.Children (Basel, Switzerland) · 2026Article
- The Link Between Dysbiosis, Inflammation, Oxidative Stress, and Asthma-The Role of Probiotics, Prebiotics, and Antioxidants.Nutrients · 2024Review
- Increased Oxidative Stress in Asthma-Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices.Biomedicines · 2022Article
- Asthma, allergy and vitamin E: Current and future perspectives.Free radical biology & medicine · 2022Article
- Lipid Nutrition in Asthma.Cell biochemistry and biophysics · 2021Review
- Review
- Delineation of the Individual Effects of Vitamin E Isoforms on Early Life Incident Wheezing.The Journal of pediatrics · 2019Article
- Update on Vitamin E and Its Potential Role in Preventing or Treating Bronchopulmonary Dysplasia.Neonatology · 2018Review
- Diet and Asthma: Is It Time to Adapt Our Message?Nutrients · 2017Review
- Article
- Lifetime Increased Risk of Adult Onset Atopic Dermatitis in Adolescent and Adult Patients with Food Allergy.International journal of molecular sciences · 2016Article
- Article
- Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice.Environmental health perspectives · 2016Article
- Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms.Mediators of inflammation · 2016Review
- Diet and asthma: an update.Current opinion in allergy and clinical immunology · 2015Review
- Phenotypes, Risk Factors, and Mechanisms of Adult-Onset Asthma.Mediators of inflammation · 2015Review
- Adult-onset asthma prevention. Should we be investing in antioxidant defense?American journal of respiratory and critical care medicine · 2015Article
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
rationaleHost antioxidant defense, consisting of enzymatic antioxidant activity and nonenzymatic antioxidant micronutrients, is implicated in asthma pathogenesis. Studies of antioxidant defense and adult incident asthma have either used measures of antioxidants estimated from questionnaires or not considered enzymatic aspects of host defense.
objectivesWe conducted the first study designed and powered to investigate the association of antioxidant defenses on adult incident asthma.
methodsIn a nested case-control study, we followed Shanghai women (aged 40-70 years) without prevalent asthma at baseline, over 8 years. Subjects with incident asthma were ascertained prospectively by gold standard testing of symptomatic women and matched to two asymptomatic control subjects. MEASUREMENTS AND MAIN
resultsBaseline urinary F2-isoprostanes, plasma concentrations of antioxidant micronutrients (tocopherols, xanthines, carotenes, and lycopene), and antioxidant enzyme activity (platelet-activating factor acetylhydrolase [PAF-AH] and superoxide dismutase) were measured from samples collected before disease onset. Among 65,372 women, 150 (0.24%) developed asthma. F2-isoprostane levels before asthma onset were not different between cases and control subjects. Doubling of α-tocopherol concentrations and PAF-AH activity was associated with 50 and 37% decreased risk of incident asthma (α-tocopherol: adjusted odds ratio = 0.52; 95% confidence interval, 0.32-0.84; PAF-AH: adjusted odds ratio = 0.63; 95% confidence interval, 0.42-0.93).
conclusionsIn this prospective study, α-tocopherol, within normal reference ranges, and PAF-AH enzymatic activity were associated with decreased asthma development. These modifiable risk factors may be an effective strategy to test for primary asthma prevention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.