ArticleCell regeneration (London, England)2012
SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1.
Article in Cell regeneration (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- SNX17 Mediates Dendritic Spine Maturation via p140Cap.Molecular neurobiology · 2024Article
- Sorting Out Sorting Nexins Functions in the Nervous System in Health and Disease.Molecular neurobiology · 2021Review
- Human Papillomavirus 16 L2 Recruits both Retromer and Retriever Complexes during Retrograde Trafficking of the Viral Genome to the Cell Nucleus.Journal of virology · 2021Article
- The Role of Sorting Nexin 17 in Cardiac Development.Frontiers in cardiovascular medicine · 2021Article
- Article
- Papillomaviruses and Endocytic Trafficking.International journal of molecular sciences · 2018Review
- Endosomal receptor trafficking: Retromer and beyond.Traffic (Copenhagen, Denmark) · 2018Review
- Review
- Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.Nature cell biology · 2017Article
- Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection.PLoS pathogens · 2015Article
- Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection.Journal of virology · 2013Article
- SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells.Cell regeneration (London, England) · 2013Article
- Reprogramming of trunk neural crest to a cranial crest-like identity alters their transcriptome and developmental potential.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNotch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent cell which induces proteolytic cleavages and the activation of the receptor. A unique feature of the Notch signaling is that processes such as modification, endocytosis or recycling of the ligand have been reported to play critical roles during Notch signaling, however, the underlying molecular mechanism appears context-dependent and often controversial.
resultsHere we identified SNX17 as a novel regulator of the Notch pathway. SNX17 is a sorting nexin family protein implicated in vesicular trafficking and we find it is specifically required in the ligand-expressing cells for Notch signaling. Mechanistically, SNX17 regulates the protein level of Jag1a on plasma membrane by binding to Jag1a and facilitating the retromer-dependent recycling of the ligand. In zebrafish, inhibition of this SNX17-mediated Notch signaling pathway results in defects in neurogenesis as well as pancreas development.
conclusionsOur results reveal that SNX17, by acting as a cargo-specific adaptor, promotes the retromer dependent recycling of Jag1a and Notch signaling and this pathway is involved in cell fate determination during zebrafish neurogenesis and pancreas development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.