Evidence map›Paper›PMID 25408852›Full record

ArticleMediterranean journal of hematology and infectious diseases2014

Peripheral red blood cell split chimerism as a consequence of intramedullary selective apoptosis of recipient red blood cells in a case of sickle cell disease.

Marco Marziali, Antonella Isgrò, Pietro Sodani, Javid Gaziev, Daniela Fraboni, Katia Paciaroni, Cristiano Gallucci, Cecilia Alfieri, Andrea Roveda, Gioia De Angelis and 4 more

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In one paragraph

Article in Mediterranean journal of hematology and infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Marco MarzialiInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Antonella IsgròInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Pietro SodaniInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Javid GazievInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Daniela FraboniDepartment of Biopathology and Diagnostic Images, Polyclinic of Tor Vergata Foundation, Rome, Italy.
Katia PaciaroniInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Cristiano GallucciInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Cecilia AlfieriInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Andrea RovedaInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Gioia De AngelisInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Luisa CardarelliInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Michela RibersaniInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Marco AndreaniLaboratory of Immunogenetics and Transplant Biology, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata"
Guido LucarelliInternational Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome "Tor Vergata" Italy.
Policlinico Tor Vergata · ITUniversity of Rome Tor Vergata · ITIstituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic cellular gene therapy through hematopoietic stem cell transplantation is the only radical cure for congenital hemoglobinopathies like thalassemia and sickle cell anemia. Persistent mixed hematopoietic chimerism (PMC) has been described in thalassemia and sickle cell anemia. Here, we describe the clinical course of a 6-year-old girl who had received bone marrow transplant for sickle cell anemia. After the transplant, the patient showed 36% donor hematopoietic stem cells in the bone marrow, whereas in the peripheral blood there was evidence of 80% circulating donor red blood cells (RBC). The analysis of apoptosis at the Bone Marrow level suggests that Fas might contribute to the cell death of host erythroid precursors. The increase in NK cells and the regulatory T cell population observed in this patient suggests that these cells might contribute to the condition of mixed chimerism.

Identifiers

PMID25408852
PMCPMC4235471
OpenAlexW2151283236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.