Evidence map›Paper›PMID 25408813›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2014

Intravesical treatment with highly-concentrated hyaluronic acid and chondroitin sulphate in patients with recurrent urinary tract infections: Results from a multicentre survey.

Antonio Cicione, Francesco Cantiello, Giuseppe Ucciero, Andrea Salonia, Marco Torella, Marco De Sio, Riccardo Autorino, Antonio Carbone, Martin Romancik, Roman Tomaskin and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  11. The immune responses to differentFrontiers in immunology · 2022
    Review
  12. Urinary Tract Infection in Parkinson's Disease.Journal of Parkinson's disease · 2022
    Review
  13. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Antonio CicioneDepartment of Urology & Research Doctorate Urology Program, Magna Graecia University, Catanzaro, Italy;
Francesco CantielloDepartment of Urology & Research Doctorate Urology Program, Magna Graecia University, Catanzaro, Italy;
Giuseppe UccieroDepartment of Urology & Research Doctorate Urology Program, Magna Graecia University, Catanzaro, Italy;
Andrea SaloniaDepartment of Urology, University Vita-Salute San Raffaele, Milano, Italy;
Marco TorellaGynaecology Unit, Second University of Naples, Napoli, Italy;
Marco De SioUrology Unit, Second University of Naples, Napoli, Italy;
Riccardo AutorinoUrology Unit, Second University of Naples, Napoli, Italy;
Antonio CarboneUnit of Urology - ICOT, Sapienza University of Rome, Latina, Italy;
Martin RomancikDepartment of Urology, St. Cyril and Method University Hospital, Bratislava, Slovakia;
Roman TomaskinDepartment of Urology, Faculty Hospital of Martin (MFN), Martin, Slovakia.
Rocco DamianoDepartment of Urology & Research Doctorate Urology Program, Magna Graecia University, Catanzaro, Italy;
Magna Graecia University · ITUniversity of Campania "Luigi Vanvitelli" · ITComenius University Bratislava · SKMartin University Hospital · SKUniversity of Naples Federico II · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe assess the effectiveness of intravesical instillation of hyaluronic acid (HA) and chondroitin sulphate (CS) as a non-antibiotic treatment option for prophylaxis of recurrent urinary tract infections (UTIs) in female patients.

methodsThis was a retrospective cohort study involving 7 European institutions. We included patients with recurrent UTIs who received intravesical instillations of Ialuril (IBSA International) (50 mL HA 1.6% and CS 2% solution) between January 2010 and March 2012. Medication schedule, length of follow-up, recurrence infection time, number of UTIs/patients/year, patient quality of life, subjective symptoms score, and treatment-emergent side effects were recorded and analyzed.

resultsIn total, 157 women (mean age: 54.2 ± 4.1 years) were included in the analysis. All patients had at least 12 months follow-up. After 4 weekly and 5 monthly HA-CS bladder instillations, UTI episodes decreased from 4.13 ± 1.14 to 0.44 ± 0.50 (p = 0.01) at 12 months, while recurrent UTI time prolonged from 94.8 ± 25.1 days to 178.4 ± 37.3 days (p = 0.01) at 12 months. An improvement in symptoms and quality of life was achieved. A medium-depth pain after medication instillation was the most reported side effect. Regression model analysis showed significant risk factors in developing new UTI episodes: being more than 50 years old and having more than 4 UTI episodes per year (OR 3.41; CI 95%; 1.51-7.71, p = 0.003 and OR 3.31; CI 95% 1.51-7.22; p = 0.003, respectively). Retrospective design and lack of a control group represent two main limitations of the study.

conclusionsRestoring glycosaminoglycans bladder layer therapy is a promising non-antibiotic therapy to prevent recurrent UTIs.

Identifiers

PMID25408813
PMCPMC4216305
OpenAlexW1879718348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.