Evidence map›Paper›PMID 25408807›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2014

Short-term perioperative outcomes of patients treated with radical cystectomy for bladder cancer included in the National Surgical Quality Improvement Program (NSQIP) database.

Giorgio Gandaglia, Briony Varda, Akshay Sood, Daniel Pucheril, Ramdev Konijeti, Jesse D Sammon, Shyam Sukumar, Mani Menon, Maxine Sun, Steven L Chang and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02880176 (Steps to Eliminate Postoperative Problems), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02880176 nacompletednot on this mapstarted 2016, after this paper: background citation

Steps to Eliminate Postoperative Problems

TypeinterventionalSponsorUniversity of PennsylvaniaRan2016 to 2019Enrolled34ConditionsBladder CancerArmsFinancial Incentive to Increase Ambulation
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Clinical utility of routine postoperative serial hemoglobin measurements in patients undergoing radical cystectomy for urothelial carcinoma.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023
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  16. Preoperative nutritional factors and outcomes after radical cystectomy: A narrative review.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2017
    Review
  17. Article
  18. WBC Associates with Readmission Following Cystectomy.Bladder cancer (Amsterdam, Netherlands) · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giorgio GandagliaCancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, QC; ; Urological Research Institute, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy;
Briony VardaCancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, QC; ; Division of Urologic Surgery and Center for Surgery and Public Health, Brigham and Women's Hospital / Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;
Akshay SoodVattikuti Urology Institute, Henry Ford Health System, Detroit, MI;
Daniel PucherilVattikuti Urology Institute, Henry Ford Health System, Detroit, MI;
Ramdev KonijetiDivision of Urologic Surgery and Center for Surgery and Public Health, Brigham and Women's Hospital / Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;
Jesse D SammonVattikuti Urology Institute, Henry Ford Health System, Detroit, MI;
Shyam SukumarCancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, QC;
Mani MenonVattikuti Urology Institute, Henry Ford Health System, Detroit, MI;
Maxine SunCancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, QC;
Steven L ChangDivision of Urologic Surgery and Center for Surgery and Public Health, Brigham and Women's Hospital / Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;
Francesco MontorsiUrological Research Institute, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy;
Adam S KibelDivision of Urologic Surgery and Center for Surgery and Public Health, Brigham and Women's Hospital / Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;
Quoc-Dien TrinhDivision of Urologic Surgery and Center for Surgery and Public Health, Brigham and Women's Hospital / Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe report the contemporary outcomes of radical cystectomy (RC) in patients with bladder cancer using a national, prospective perioperative database specifically developed to assess the quality of surgical care.

methodsThe National Surgical Quality Improvement Program (NSQIP) database was queried from 2006 to 2011 for RC. Data on postoperative complications, operative time, length of stay, blood transfusions, readmission, and mortality within 30 days from surgery were abstracted.

resultsOverall, 1094 patients undergoing RC were identified. Rates of overall complications, transfusions, prolonged length of hospitalization, readmission, and perioperative mortality were 31.1%, 34.4%, 25.9%, 20.2%, and 2.7%, respectively. Body mass index represented an independent predictor of overall complications on multivariate analysis (p = 0.04). Baseline comorbidity status was associated with increased odds of postoperative complications, prolonged operative time, transfusion, prolonged hospitalization, and perioperative mortality. In particular, patients with cardiovascular comorbidities were 2.4 times more likely to die within 30 days following cystectomy compared to their healthier counterparts (p = 0.04). Men had lower odds of prolonged operative time and blood transfusions (p ≤ 0.03). Finally, the receipt of a continent urinary diversion was the only predictor of readmission (p = 0.02). Our results are limited by their retrospective nature and by the lack of adjustment for hospital and tumour volume.

conclusionsComplications, transfusions, readmission, and perioperative mortality remain relatively common events in patients undergoing RC for bladder cancer. In an era where many advocate the need for prospective multi-institutional data collection as a means of improving quality of care, our study provides data on short-term outcomes after RC from a national quality improvement initiative.

Identifiers

PMID25408807
PMCPMC4216299

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.