Evidence map›Paper›PMID 25408692›Full record

ReviewFrontiers in microbiology2014

From lifetime to evolution: timescales of human gut microbiota adaptation.

Sara Quercia, Marco Candela, Cristina Giuliani, Silvia Turroni, Donata Luiselli, Simone Rampelli, Patrizia Brigidi, Claudio Franceschi, Maria Giulia Bacalini, Paolo Garagnani and 1 more

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
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  4. Omics Approaches to Unraveling the Complexity of the Gut-Lung Axis.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  5. Article
  6. Article
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  9. Article
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  13. Review
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  15. Article
  16. Beneficial Effects of Laurel (Molecules (Basel, Switzerland) · 2022
    Article
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  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara QuerciaDepartment of Pharmacy and Biotechnology, University of Bologna Bologna, Italy.
Marco CandelaDepartment of Pharmacy and Biotechnology, University of Bologna Bologna, Italy.
Cristina GiulianiBiGEA, Department of Biological, Geological and Environmental Sciences, Laboratory of Molecular Anthropology & Centre for Genome Biology, University of Bologna Bologna, Italy.
Silvia TurroniDepartment of Pharmacy and Biotechnology, University of Bologna Bologna, Italy.
Donata LuiselliBiGEA, Department of Biological, Geological and Environmental Sciences, Laboratory of Molecular Anthropology & Centre for Genome Biology, University of Bologna Bologna, Italy.
Simone RampelliDepartment of Pharmacy and Biotechnology, University of Bologna Bologna, Italy.
Patrizia BrigidiDepartment of Pharmacy and Biotechnology, University of Bologna Bologna, Italy.
Claudio FranceschiDIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna Bologna, Italy ; CIG, Interdepartmental Centre "L. Galvani" CIG, University of Bologna Bologna, Italy ; IRCSS, Institute of Neurological Sciences of Bologna Bologna, Italy ; IGM-CNR, Institute of Molecular Genetics, Unit of Bologna IOR Bologna, Italy ; CNR, Institute of Organic Synthesis and Photoreactivity (ISOF) Bologna, Italy.
Maria Giulia BacaliniDIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna Bologna, Italy ; CIG, Interdepartmental Centre "L. Galvani" CIG, University of Bologna Bologna, Italy.
Paolo GaragnaniDIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna Bologna, Italy ; CIG, Interdepartmental Centre "L. Galvani" CIG, University of Bologna Bologna, Italy ; CRBA, Center for Applied Biomedical Research, St. Orsola-Malpighi University Hospital Bologna, Italy.
Chiara PirazziniDIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna Bologna, Italy ; CIG, Interdepartmental Centre "L. Galvani" CIG, University of Bologna Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human beings harbor gut microbial communities that are essential to preserve human health. Molded by the human genome, the gut microbiota (GM) is an adaptive component of the human superorganisms that allows host adaptation at different timescales, optimizing host physiology from daily life to lifespan scales and human evolutionary history. The GM continuously changes from birth up to the most extreme limits of human life, reconfiguring its metagenomic layout in response to daily variations in diet or specific host physiological and immunological needs at different ages. On the other hand, the microbiota plasticity was strategic to face changes in lifestyle and dietary habits along the course of the recent evolutionary history, that has driven the passage from Paleolithic hunter-gathering societies to Neolithic agricultural farmers to modern Westernized societies.

Indexed as

agingbiological adaptationco-evolutionenvironmental stimuligut microbiota

Identifiers

PMID25408692
PMCPMC4219431

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.