Evidence map›Paper›PMID 25408625›Full record

ArticleCurrent bioactive compounds2014

DNA Cleaving "Tandem-Array" Metallopeptides Activated With KHSO

Mark A Lewis, Katie M Williams, Ya-Yin Fang, Franklin A Schultz, Eric C Long

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current bioactive compounds, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mark A LewisDepartment of Chemistry & Chemical Biology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana 46202.
Katie M WilliamsDepartment of Chemistry & Chemical Biology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana 46202.
Ya-Yin FangDepartment of Biochemistry & Molecular Biology, Howard University, 520 W Street, NW, Washington, D. C. 20059.
Franklin A SchultzDepartment of Chemistry & Chemical Biology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana 46202.
Eric C LongDepartment of Chemistry & Chemical Biology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana 46202.
Indiana University – Purdue University Indianapolis · US

Funding

PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
Metallopeptide-DNA Recognition and ReactivityR01GM062831 · NIGMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI LONG, ERIC C. · 2001 to 2004
$726k
NIGMS NIH HHS R01 GM062831NIMHD NIH HHS G12 MD007597
6 · The paper itself

Abstract

Amino terminal peptides of the general form Gly-Gly-His have been used to introduce single sites of metal binding and redox activity into a wide range of biomolecules to create bioactive compounds and conjugates capable of substrate oxidation. We report here that Gly-Gly-His-like peptides linked in a tandem fashion can also be generated leading to multi-metal binding arrays. While metal binding by the native Gly-Gly-His motif (typically to Cu

Indexed as

DNA cleavageGly-Gly-Hismetal binding peptidemetallopeptide

Identifiers

PMID25408625
PMCPMC4232849
OpenAlexW2002123375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.