ReviewAmino acids2015
Leucine is a major regulator of muscle protein synthesis in neonates.
Review in Amino acids, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 101 citations in OpenAlex.
- Plasma amino acids after human milk fortification and associations with growth in preterm infants.Pediatric research · 2026Article
- Chemical Characterization, Antioxidant Potential and Phenolic Profile of the Pulp and By-Products of Black puçá (Mouriri pusa), a Fruit from the Brazilian Cerrado region.Plant foods for human nutrition (Dordrecht, Netherlands) · 2024Article
- Double-Edge Effects of Leucine on Cancer Cells.Biomolecules · 2024Review
- Metabolomics-driven discovery of therapeutic targets for cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2024Review
- Article
- Suitable Cottonseed Protein Concentrate Supplementation in Common Carp (Antioxidants (Basel, Switzerland) · 2024Article
- Dietary supplementation withFrontiers in veterinary science · 2024Article
- Changes in Faecal and Plasma Amino Acid Profile in Dogs with Food-Responsive Enteropathy as Indicators of Gut Homeostasis Disruption: A Pilot Study.Veterinary sciences · 2023Article
- Serum metabolomic characterization in pigs in relation to birth weight category and neonatal nutrition.Journal of animal science · 2023Article
- Branched-chain amino acids regulate intracellular protein turnover in porcine mammary epithelial cells.Amino acids · 2022Article
- Dietary supplementation with branched-chain amino acids enhances milk production by lactating sows and the growth of suckling piglets.Journal of animal science and biotechnology · 2022Article
- Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index.Pediatric obesity · 2022Article
- NMR Metabonomic Profile of Preterm Human Milk in the First Month of Lactation: From Extreme to Moderate Prematurity.Foods (Basel, Switzerland) · 2022Article
- Article
- Effect of fed-batch and chemostat cultivation processes ofBioengineered · 2021Article
- Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells.Biomolecules · 2021Article
- Article
- Leucine Reconstitutes Phagocytosis-Induced Cell Death inInternational journal of molecular sciences · 2021Article
- Amino Acids in Swine Nutrition and Production.Advances in experimental medicine and biology · 2021Article
- Effects on nitrogen balance and metabolism of branched-chain amino acids by growing pigs of supplementing isoleucine and valine to diets with adequate or excess concentrations of dietary leucine.Journal of animal science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Approximately 10% of infants born in the United States are of low birth weight. Growth failure during the neonatal period is a common occurrence in low birth weight infants due to their inability to tolerate full feeds, concerns about advancing protein supply, and high nutrient requirements for growth. An improved understanding of the nutritional regulation of growth during this critical period of postnatal growth is vital for the development of strategies to improve lean gain. Past studies with animal models have demonstrated that muscle protein synthesis is increased substantially following a meal and that this increase is due to the postprandial rise in amino acids as well as insulin. Both amino acids and insulin act independently to stimulate protein synthesis in a mammalian target of rapamycin-dependent manner. Further studies have elucidated that leucine, in particular, and its metabolites, α-ketoisocaproic acid and β-hydroxy-β-methylbutyrate, have unique anabolic properties. Supplementation with leucine, provided either parenterally or enterally, has been shown to enhance muscle protein synthesis in neonatal pigs, making it an ideal candidate for stimulating growth of low birth weight infants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.